* Supported by the Grant Agency of the Czech Republic under the contracts no. 201/99/D057 and 201/01/0942. I would like to thank Petr Vilím for implementing the alldifferent constraint and for performing the empirical evaluation. I am also grateful to Ondøej Èepek for proof reading of the paper draft.

Address correspondence to: Bernhard Nieswandt, PhD Chair of Vascular Medicine, Rudolf Virchow Center DFG Research Center for Experimental Biomedicine University Clinic Würzburg Zinklesweg 10 97078 Würzburg Fon: + 49 931 201 44060 Fax: + 49 931 201 48068 E-mail: [email protected] Blood First Edition Paper, prepublished online July 29, 2009; DOI 10.1182/blood-2009-05-222273

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