Cellular and molecular approaches are being explored to find a biomarker which can predict the development of radiation induced acute toxicity prior to radiation therapy. SNPs in radiation responsive genes may be considered as an approach to develop tools for finding the inherited basis of clinical radiosensitivity. The current study attempts to screen single nucleotide polymorphisms/deletions ...

Nijmegen breakage syndrome (NBS) is a genomic instability disease caused by hypomorphic mutations in the NBS1 gene encoding the Nbs1 (nibrin) protein. Nbs1 is a component of the Mre11/Rad50/Nbs1 (MRN) complex that acts as a sensor of double strand breaks (DSBs) in the DNA and is critical for proper activation of the broad cellular response to DSBs. Conditional disruption of the murine ortholog ...

Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the Internatio...

Nijmegen Breakage Syndrome (NBS), an autosomal recessive genetic instability syndrome, is caused by hypomorphic mutation of the NBN gene, which codes for the protein nibrin. Nibrin is an integral member of the MRE11/RAD50/NBN (MRN) complex essential for processing DNA double-strand breaks. Cardinal features of NBS are immunodeficiency and an extremely high incidence of hematological malignancie...

186 LLE Review, Volume 92 Recently proposed superconducting single-photon detectors (SSPD’s), based on ultrathin, submicrometer-width NbN superconducting stripes, are characterized by picosecond response times, high quantum efficiency, broadband singlephoton sensitivity, and extremely low dark counts.1,2 The devices have immediately found a variety of applications ranging from noninvasive testi...

A comprehensive review on geometric and electronic structures, spectroscopic and energetic properties of small niobium clusters in the range from two to twenty atoms, Nbn, n = 2–20, in three different charged states is presented including a systematic comparison of quantum chemical results with available experimental data to assign the lowest-lying structures of Nbn clusters and their IR spectr...