Front Cover: The cover image is based on the Research Article Proper phosphorylation of septin 12 regulates 4 and soluble adenylyl cyclase expression to induce sperm capacitation by Han-Yu Wang et al., https://doi.org/10.1002/jcp.30951.

The hyperfine structure of highly charged 238 92 U ions with rotationally excited nuclei Abstract The hyperfine structure (hfs) of electron levels of 238 92 U ions with the nucleus excited in the low-lying rotational 2 + state with an energy E 2 + = 44.91 keV is investigated. In hydrogenlike uranium, the hfs splitting for the 1s 1/2-ground state of the electron constitutes 1.8 eV. The hyperfine...

Human laeverin/aminopeptidase Q (APQ) is a novel member of the M1 family of zinc aminopeptidases and is specifically expressed on the cell surface of extravillous trophoblasts. In this study, we examined the significance of Gln-238 of laeverin/APQ, a putative S1 site residue, by site-directed mutagenesis for its enzymatic activity and substrate specificity. Replacement of Gln-238 with Ala cause...

Isoquinolines (IQs) are natural substances with an antibiotic potential we aim to optimize. Specifically, IQ-238 is a synthetic analog of the novel-type N,C-coupled naphthylisoquinoline (NIQ) alkaloid ancisheynine. Recently, we developed and tested other IQs such as IQ-143. By utilizing genome-wide gene expression data, metabolic network modelling and Voronoi tessalation based data analysis - a...