نتایج جستجو برای: الگوی ecm

تعداد نتایج: 54612  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
H Nakahara L Howard E W Thompson H Sato M Seiki Y Yeh W T Chen

The invasion of human malignant melanoma cells into the extracellular matrix (ECM) involves the accumulation of proteases at sites of ECM degradation where activation of matrix metalloproteases (MMP) occurs. Here, we show that when membrane type 1 MMP (MT-MMP) was overexpressed in RPMI7951 human melanoma cells, the cells made contact with the ECM, activated soluble and ECM-bound MMP-2, and degr...

Journal: :Journal of the American Society of Nephrology : JASN 2015
Michael J Randles Adrian S Woolf Jennifer L Huang Adam Byron Jonathan D Humphries Karen L Price Maria Kolatsi-Joannou Sophie Collinson Thomas Denny David Knight Aleksandr Mironov Toby Starborg Ron Korstanje Martin J Humphries David A Long Rachel Lennon

Glomerular disease often features altered histologic patterns of extracellular matrix (ECM). Despite this, the potential complexities of the glomerular ECM in both health and disease are poorly understood. To explore whether genetic background and sex determine glomerular ECM composition, we investigated two mouse strains, FVB and B6, using RNA microarrays of isolated glomeruli combined with pr...

Journal: :Integrative biology : quantitative biosciences from nano to macro 2012
Ekaterina Kniazeva John W Weidling Rahul Singh Elliot L Botvinick Michelle A Digman Enrico Gratton Andrew J Putnam

Reciprocal mechanical interactions between cells and the extracellular matrix (ECM) are thought to play important instructive roles in branching morphogenesis. However, most studies to date have failed to characterize these interactions on a length scale relevant to cells, especially in three-dimensional (3D) matrices. Here we utilized two complementary methods, spatio-temporal image correlatio...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Amit Pathak Sanjay Kumar

Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cultures that more closely resemble tissue has proven challenging, because perturbations that change...

Journal: :Circulation 2005
Paul V Kochupura Evren U Azeloglu Damon J Kelly Sergey V Doronin Stephen F Badylak Irvin B Krukenkamp Ira S Cohen Glenn R Gaudette

BACKGROUND Extracellular matrix (ECM), a tissue-engineered scaffold, recently demonstrated cardiomyocyte population after myocardial implantation. Surgical restoration of myocardium frequently uses Dacron as a myocardial patch. We hypothesized that an ECM-derived myocardial patch would provide a mechanical benefit not seen with Dacron. METHODS AND RESULTS Using a canine model, a full thicknes...

Journal: :International journal of physiology, pathophysiology and pharmacology 2014
Erika Azorín Beatriz Romero-Pérez Carmen Solano-Agama María T de la Vega César G Toriz Blanca Reyes-Márquez Sirenia González-Pozos Víctor H Rosales-García Margarita González Del Pliego Myrna Sabanero María E Mendoza-Garrido

The extracellular matrix (ECM) influences different physiological and pathophysiological aspects of the cell. The ECM consists in a complex network of macromolecules with characteristic biochemical properties that allow cells to sense their environments inducing different signals and changing cell behavior. The purpose of the present study was to evaluate the participation of different ECM prot...

2014
Jeehye Sung Misun Sung Younghwa Kim Hyeonmi Ham Heon-Sang Jeong Junsoo Lee

BACKGROUND/OBJECTIVES In this study, we determined the anti-inflammatory activities and the underlying molecular mechanisms of the methanol extract from Erigeron Canadensis L. (ECM) in LPS-stimulated RAW264.7 macrophage cells. MATERIALS/METHODS The potential anti-inflammatory properties of ECM were investigated by using RAW264.7 macrophages. We used western blot assays and real time quantitat...

Journal: :Journal of physics 2022

Abstract The elliptic curve is an important topic in number theory. In 1987, Lenstra discovered the elliptic-curve factorization method (ECM). [4] Nevertheless, until now, no research can have complete detailed codes Wolfram Mathematica. This article will state definition of curve, analyze this ECM algorithm, and build a code s Finally, completed for 1820099 by experiment, which prove that ECM,...

2017
Stephen S. Wanyonyi Amit Kumar Ryan Du Preez Christophe Lefevre Kevin R. Nicholas

BACKGROUND The unique lactation strategy of the tammar wallaby (Macropus eugeni) has been invaluable in evaluating the role of lactogenic hormones and the extracellular matrix (ECM) in the local control of mammary gland function. However molecular pathways through which hormones and ECM exert their effect on wallaby mammary gland function remain unclear. This study undertakes transcriptome anal...

Journal: :Pharmacological reviews 2009
Hannu Järveläinen Annele Sainio Markku Koulu Thomas N Wight Risto Penttinen

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and noncollagenous glycoproteins. In addition to being necessary structural components, ECM molecules exhibit important functional roles in the control of key cellular events such as adhesion, migration, proliferati...

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