Scanning electrochemical microscopic (SECM) imaging of oligonucleotides and polynucleotides (poly[G] and calf thymus DNA) immobilized onto aldehyde-modified glass substrates was achieved through oxidation of guanine residues on the DNA molecules by SECM tip-generated Ru(bpy)3 3 . Several parameters affecting the tip current associated with the guanine oxidation reaction (e.g. tip/substrate sepa...

Potentiometric pH selective tips for scanning electrochemical microscopy (SECM) have been developed and used to image local pH changes in a variety of model chemical systems. Images of pH profiles around a platinum microelectrode during water reduction, a corroding disk of silver iodide in aqueous potassium cyanide, a disk of immobilized urease hydrolyzing urea, and a disk of immobilized yeast ...

Over the last 2 decades, scanning electrochemical microscopy (SECM) has been extensively employed for topographic imaging and mapping surface reactivity on the micrometer scale. We used flat, polished nanoelectrodes as SECM tips to carry out feedback mode imaging of various substrates with nanoscale resolution. Constant-height and constant-current images of plastic and Au compact disc surfaces ...

Scanning electrochemical microscopy (SECM) is a powerful technique that can provide chemical identity, quantification, and spatiotemporal information on biosurfaces. The ability of SECM for noninvasive high-resolution imaging has made it valuable the study cell phenotypes functions. This review focuses latest advances biosurface imaging. measurements different biomarkers, including oxygen consu...

Recent progress has seen scanning electrochemical microscopy (SECM) emerge as a powerful technique for probing physicochemical interfacial processes, beyond the solid/liquid and electrode/electrolyte interfaces that were originally of primary interest. This review (with 92 references) assesses recent developments in SECM as a methodology for investigating liquid/liquid and liquid/gas interfaces...

The reduction of the rhenium aryldiazenido complex [Cp*Re(CO)z(P-N2C&OMe)][BFJ results in the formation of the corresponding metal-bound dinitrogen complex Cp*Re(C0)2(N2). The mechanism of this transformation has been investigated by cyclic voltammetry (0, controlled-potentia1 electrolysis (CPE), and scanning electrochemical microscopy (SECM). The SECM analysis supported an electrochemical E& m...

The scanning electrochemical microscope (SECM), operating in the feedback mode, was used to image localized surface reactions of redox enzymes at the micrometer level. Surfaces imaged with the SECM included glucose oxidase immobilized within 8-microns-diameter pores of a filtration membrane and individual whole mitochondria with active NADH cytochrome reductase enzymes in their outer membranes....