Many groups of organisms show greater species richness in the tropics than in the temperate zone, particularly in tropical montane regions. Forty years ago, Janzen suggested that more limited temperature seasonality in the tropics leads to greater climatic zonation and more climatic barriers to organismal dispersal along elevational gradients in the tropics relative to temperate regions. These ...

The aryl hydrocarbon receptor (AHR) is a transcriptional activator of genes encoding a group of drug-metabolizing enzymes, including cytochrome P450 1A1 (CYP1A1), glutathione S-transferase, tumor-associated aldehyde dehydrogenase and quinone reductase. Both the constitutive and inducible expression of these genes in the liver is zonated, i.e., dominant in hepatocytes of the centrilobular region...

The broad biogeographic distribution of Hesperornis fossils in Late Cretaceous Western Interior Seaway deposits has prompted questions about whether they endured polar winters or migrated between mid- and high latitudes. Here, we compare microstructures of hesperornithiform long bones from Kansas and the Arctic to investigate whether migration or Late Cretaceous polar climate affected bone grow...

More predictive in vitro liver models are a critical requirement for preclinical screening of compounds demonstrating hepatotoxic liability. 3D liver spheroids have been shown to have an enhanced functional lifespan compared to 2D monocultures; however a detailed characterisation of spatiotemporal function and structure of spheroids still needs further attention before widespread use in industr...

Nitrogen fixation and colonization by associative cyanobacteria in the aerial roots (pneumatophores) of black mangrove trees was evaluated in situ at Balandra lagoon, Baja California Sur, Mexico, for 18 consecutive months. Year-round vertical zonation of cyanobacterial colonization was determined along the pneumatophores. The bottom part close to the sediment was colonized mainly by nonheterocy...

Concomitant steatosis in chronic hepatitis C is associated with fibrosis and unfavorable treatment outcome. Central zone injury in nonalcoholic steatohepatitis (NASH) manifests as central portalization, with centrizonal microvessels and ductular reaction. We investigated whether central portalization in steatotic HCV biopsies would identify patients with metabolic risk factors for NASH. Liver b...

بخش اورژانس یکی از شلوغ‌ترین بخش‌های یک بیمارستان است و بهبود عملکرد این تأثیر بسیاری در کیفیت ارائه خدمات دارد. اخیراً پژوهشگران به­‌دلیل تمرکز مهندسی تاب‌آوری مدیریت ناب بر کارایی سیستم‌ها توجه بسیار زیادی به دو دیدگاه کنار یکدیگر داشته‌اند. هدف پژوهش، رویکردی یکپارچه برای ارزیابی مبتنی شاخص‌های با ارتقای رضایت شغلی کاهش هزینه‌های درمانی واحد خصوصی است. منظور، ابتدا شناسایی مؤثر، مدل مفهومی مس...

The subcommissural organ of vertebrates secretes glycoproteins into the third ventricle that condense to form Reissner's fiber (RF). Antibodies raised against the bovine RF-glycoproteins reacted with the floor plate (FP) cells of two teleost (Oncorhynchus kisutch, Sparus aurata) and two amphibian (Xenopus laevis, Batrachyla taeniata) species. At the ultrastructural level, the immunoreactivity w...

Here we report that prioritizing sites in order of rarity-weighted richness (RWR) is a simple, reliable way to identify sites that represent all species in the fewest number of sites (minimum set problem) or to identify sites that represent the largest number of species within a given number of sites (maximum coverage problem). We compared the number of species represented in sites prioritized ...

Landslides are major natural hazards which not only result in the loss of human life but also cause economic burden on the society. Therefore, it is essential to develop suitable models to evaluate the susceptibility of slope failures and their zonations. This paper scientifically assesses various methods of landslide susceptibility zonation in GIS environment. A comparative study of Weights of...