Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cyclooxygenase2 (COX-2) inhibitors, using three different methods: comparative molecular field analysis (CoMFA) with partial least squares (PLS) fit; mole...

Self-assembled nano-micelles of amphiphilic polymers represent a novel anticancer drug delivery system. However, their full clinical utilization remains challenging because the quantitative structure-property relationship (QSPR) between the polymer structure and the efficacy of micelles as a drug carrier is poorly understood. Here, we developed a series of QSPR models to account for the drug lo...

Circles of Care grantees were provided the opportunity to develop a locally relevant definition of serious emotional disturbance that would be used to define what type of emotional, behavioral, and mental disability would be required to receive services. After conducting detailed assessments of the definition in the guidance for applicants GFA and the definitions used by others in their respect...

A multi-scale attention-based model (MSAM) is proposed as a surrogate for uncertainty analysis (UA) in ground penetrating radar (GPR) simulation. Instead thousand of full-wave simulations, the converts uncertain inputs to electric fields, and output effectively quantified. Global feature aggregation (GFA) module local affinity reconstruction (LAR) are presented improve representation capability...

ادغام داده‌ها بین حسگرهای مختلف می‌تواند موجب استخراج اطلاعات با دقت و کیفیت بالاتر گردد بهبود تشخیص تهدیدهای هسته‌ای را به همراه داشته باشد. در این تحقیق، ردیابی چشمه متحرک استفاده از تلفیق داده­های سیستم آشکارساز پرتوی دوربین نظارتی مورد مطالعه قرار گرفت است. بدین منظور الگوریتمی جهت ایجاد همبستگی تصاویر دریافتی توسط شمارش طراحی شده است تا مسیر حرکت جسمی که بیش­ترین ثبت آشکارسازی دارد عنوان ا...

Mobile IP has been defined by Third Generation Partnership Project 2(3GPP2) to be the mobility solution for the next generation cellular networks. The Mobile IP related issues therefore become important and popular. Mobile IP provides the Mobile Node (MN) the ability of roaming around a foreign domain. An MN needs to register with its Home Agent (HA) through the attached Foreign Agent (FA) when...

In recent years, CuZr-based bulk metallic glass (BMG) composites ductilized by a shape memory B2 CuZr phase have attracted great attention owing to their outstanding mechanical properties. However, the B2 CuZr phase for most CuZr-based glass-forming compositions is only stable at very high temperatures, leading to the uncontrollable formation of B2 crystals during quenching. In this work, by in...

Despite intense interest in the discovery and design of metallic glasses, efficient a priori identification novel glass-formers without need for time-consuming experimental characterization has remained an unattained goal. To address this, we use geometric alignment density-based clustering algorithms to quantitatively describe short-range atomic structure simulated liquid state five known glas...

The gfa gene encodes glial fibrillary acidic protein (GFAP), an intermediate-filament protein expressed primarily in glial cells. We have used in vitro transcription studies to show that the basal level of transcription of the human gene encoding GFAP is controlled by two distinct initiators--i.e., promoter elements that direct transcription from a specific start site. One initiator is located ...