نتایج جستجو برای: اسپات 5
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آب شدن یخهای قطب، میتواند، مناسبات قدرت در سطح بینالمللی را دستخوش تغییر کند، کشف مسیرهای دریانوردی جدید، کوتاه شدن راه ارتباطی بین غرب و شرق، کشف منابع استراتژیک، مسئله مرزهای مورد مناقشه، منازعات کانادا – نروژ، تلاش برای مهار قدرت چین توسط آمریکا و متحدان، و تلاش چین برای ایجاد قدرت متوازن و تبدیل کردن چین به قدرت بزرگ در محور شمال و ... سبب شده است تا گرینلند تبدیل به هات اسپات ژئوپلیتیک ...
Adenosine Analogs, Conformation, NMR The solution conformation of adenosine(/Oribosides modified at the 2', 3' or 5' position is derived from the analysis o f the HRNM R spectra of the ribose protons. The conformational equilibria of the furanoside rings are described by the two state N <-+ S model introduced by Altona and Sundaralingam. The new compounds studied are: 2'-thiobenzoyl-2'-deoxyade...
DNA methylation plays an important role in the epigenetic regulation of mammalian gene expression. TET (ten-eleven translocation) proteins, newly discovered demethylases, have sparked great interest since their discovery. TET proteins catalyze 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in 3 consecutive Fe(II)- and 2-oxoglutarate (2-OG)-dependent oxidati...
Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD). Recently, 3 additional cytosine modifications have been identified (5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine), which are thought to be intermediate steps in the demethyl...
Methylation of cytosine to 5-methylcytosine (5mC) is important for gene expression, gene imprinting, X-chromosome inactivation, and transposon silencing. Active demethylation in animals is believed to proceed by DNA glycosylase removal of deaminated or oxidized 5mC. In plants, 5mC is removed from the genome directly by the DEMETER (DME) family of DNA glycosylases. Arabidopsis thaliana DME excis...
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