To study the effect of positive airway pressure (Paw) on the pressure gradient for venous return [the difference between mean systemic filling pressure (Pms) and right atrial pressure (Pra)], we investigated 10 patients during general anesthesia for implantation of defibrillator devices. Paw was varied under apnea from 0 to 15 cmH(2)O, which increased Pra from 7.3 +/- 3.1 to 10.0 +/- 2.3 mmHg a...

Over the last decade, a wealth of research has examined the potential benefits of product recommendation agents (PRAs) for improving outcomes for e-commerce consumers and vendors. To date, however, this research has largely overlooked the fundamentally social nature of shopping. In particular, people often shop collaboratively (together) and for hedonic reasons (for enjoyment), but researchers ...

Plasma renin activity (PRA) may be high among teenage and young adult insulin-dependent diabetic subjects. Supine PRA and stimulated PRA were therefore measured in 50 female and 50 male diabetic subjects, 13-20 years old, diagnosed before the age of 16. Fifty percent have been restudied after 4.6 +/- 0.2 (mean +/- SEM) years. Initially, 43% had high PRA (supine 4.0 +/- 0.37, stimulated 12.02 +/...

BACKGROUND We sought to evaluate plasma renin activity (PRA) levels and risk of mortality and cardiovascular events among individuals with elevated blood pressure [systolic blood pressure (SBP) ≥ 140 mmHg] and those with controlled blood pressure (SBP < 140 mmHg) in a large diverse population. METHODS A retrospective cohort study between January 1, 2007, and December 31, 2013, among adults (≥...

BACKGROUND Renin-angiotensin-aldosterone system (RAAS) activation in heart failure with reduced ejection fraction (HFREF) is detrimental through promotion of ventricular remodeling and salt and water retention. AIMS The aims of this article are to describe RAAS activity in distinct HFREF populations and to assess its prognostic impact. METHODS Venous blood samples were prospectively obtaine...

1, 25-Dihydroxycholechalciferol (calcitriol) and 19-nor-1, 25-dihydroxyvitamin D2 (paricalcitol) are vitamin D receptor (VDR) agonists. Previous data suggest VDR agonists may actually increase renin-angiotensin activity, and this has always been assumed to be mediated by hypercalcemia. We hypothesized that calcitriol and paricalcitol would increase plasma renin activity (PRA) independently of p...

Predicted range aggregate (PRA) query is an important researching issue in spatio-temporal databases. Recent studies have developed two major classes of PRA query methods: (1) accurate approaches, which search the common moving objects indexes to obtain an accurate result; and (2) estimate methods, which utilize approximate techniques to estimate the result with an acceptable error. In this pap...

Atchison DK, Harding P, Beierwaltes WH. Vitamin D increases plasma renin activity independently of plasma Ca via hypovolemia and -adrenergic activity. Am J Physiol Renal Physiol 305: F1109 –F1117, 2013. First published August 7, 2013; doi:10.1152/ajprenal.00010.2013.—1, 25-Dihydroxycholechalciferol (calcitriol) and 19-nor-1, 25-dihydroxyvitamin D2 (paricalcitol) are vitamin D receptor (VDR) ago...