Transmembrane electroneutral transport mechanisms [e.g., Na/H exchange, Cl/HCO3 exchange, (K + Cl) cotransport] have recently been identified in a wide variety of cell types. If these exchanges sum to give a net electroneutral Na/K exchange, they may hyperpolarize the membrane potential beyond the value calculated from the Mullins-Noda equation, provided the cell maintains steady state intracel...

We study properties of the solutions of a family of second order integrodifferential equations, which describe the large scale dynamics of a class of microscopic phase segregation models with particle conserving dynamics. We first establish existence and uniqueness as well as some properties of the instantonic solutions. Then we concentrate on formal asymptotic (sharp interface) limits. We argu...

Abstract. We study coarsening of a binary mixture within the Mullins-Sekerka evolution in the regime where one phase has small volume fraction φ ¿ 1. Heuristic arguments suggest that the energy density, which represents the inverse of a typical length scale, decreases as φt−1/3 as t → ∞. We prove rigorously a corresponding weak lower bound. Moreover, we establish a stronger result for the two-d...

C. Celum, A. Wald, J.R. Lingappa, A.S. Magaret, R.S. Wang, N. Mugo, A. Mujugira, J.M. Baeten, J.I. Mullins, J.P. Hughes, E.A. Bukusi, C.R. Cohen, E. Katabira, A. Ronald, J. Kiarie, C. Farquhar, G.J. Stewart, J. Makhema, M. Essex, E. Were, K.H. Fife, G. de Bruyn, G.E. Gray, J.A. McIntyre, R. Manongi, S. Kapiga, D. Coetzee, S. Allen, M. Inambao, K. Kayitenkore, E. Karita, W. Kanweka, S. Delany, H...

1 Hubrecht Laboratory (NIOB-KNAW NIOB), Utrecht, The Netherlands, 2 University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 3 Harvard Medical School and Children’s Hospital Pediatrics, Cambridge, Massachusetts, United States of America, 4 Hubrecht Laboratory (NIOB-KNAW NIOB), Utrecht, The Netherlands, 5 Marc Ekker, Center for Advanced Research in Environm...

Synovial chondromatosis is a rare condition in which osteocartilaginous nodules are formed by synovial metaplasia and become intra-articular loose bodies. It is usually monarticular, most commonly affecting the knee and is regarded as invariably benign. There are reports ofmalignant change, but only the two case studies of Mullins, Berard and Eisenberg (1965) and of Dunn et at. (1974) fully doc...