An important metric for gauging the impact that a synthetic route has on chemical resources, cost, and sustainability is process mass intensity (PMI). Calculating overall PMI or step-PMI given synthesis from description more common across pharmaceutical industry, especially in chemistry departments. As with other companies, our company established strong track record of delivering Corporate Sus...

Recent work has led to the ability to perform space efficient, approximate counting over large vocabularies in a streaming context. Motivated by the existence of data structures of this type, we explore the computation of associativity scores, otherwise known as pointwise mutual information (PMI), in a streaming context. We give theoretical bounds showing the impracticality of perfect online PM...

Abstract Aims The diagnosis of periprocedural myocardial infarction (PMI) after coronary artery bypass graft (CABG) is based on biochemical markers along with clinical and/or instrumental findings. However, there not a clear cut-off value high-sensitivity cardiac troponin (hs-cTn) to identify PMI. We hypothesized that isolated hs-cTn concentrations in the first 24 h following CABG could predict...

Using Hermite’s formulation of polynomial stability conditions, static output feedback (SOF) controller design can be formulated as a polynomial matrix inequality (PMI), a (generally nonconvex) nonlinear semidefinite programming problem that can be solved (locally) with PENNON, an implementation of a penalty method. Typically, Hermite SOF PMI problems are badly scaled and experiments reveal tha...

Project management skills and professional certification are quickly developing into required core practice (Hammond et al., 2006). Peter Shears, CEO of the Australian Institute of Project Management (AIPM), stated at a April, 2006, conference, that there was increased demand for skilled project managers within all organizations across all industry sectors (Hammond et al., 2006). AIPM is an Aus...

In his January 2015 State of the Union address, President Barack Obama announced a new Precision Medicine Initiative (PMI) to personalize approaches toward improving health and treating disease (www.whitehouse.gov/precision-medicine). He stated that the goal of such an initiative was "to bring us closer to curing diseases like cancer and diabetes, and to give all of us access to the personalize...

BACKGROUND Metabolic syndrome (MetS) has been reported as a risk factor for cardiovascular events. The aim of the present study is to investigate the association between chronic angiotensin-converting enzyme inhibitors (ACE-I) therapy and the rate of periprocedural myocardial infarction (PMI) after elective coronary stenting among patients with MetS. METHODS The inclusion criteria were MetS a...

BACKGROUND Creatine kinase-MB (CK-MB) elevation after percutaneous coronary intervention (PCI) has been associated with increased risk for mortality. Although most studies have defined periprocedural myocardial infarction (pMI) as an elevation in CK-MB >3× upper limit of normal (ULN), use of different CK-MB assays and variation in site-specific definitions of the ULN may limit the value of such...

BACKGROUND The aim of this study performed in patients undergoing major orthopedic surgery was to assess the impact of changes in practice on both the incidence of postoperative myocardial ischemia (PMI) detected by serial measurements of troponin Ic and long-term cardiac outcome. METHODS During a 3-yr period, troponin Ic was measured on the first 3 days after major orthopedic surgery in a mu...

Background—Myocardial scars harbor areas of slow conduction and display abnormal electrograms. Pace-mapping at these sites can generate a 12-lead ECG morphological match to a targeted ventricular tachycardia (VT), and in some instances, multiple exit morphologies can result. At times, this can also result in the initiation of VT, termed pace-mapped induction (PMI). We hypothesized that in patie...