Human plasmacytoid dendritic cells (pDC) are important modulators of adaptive T cell responses during viral infections. Recently, we found that human pDC produce the serine protease granzyme B (GrB), thereby regulating T cell proliferation in a GrB-dependent manner. In this study, we demonstrate that intrinsic GrB production by pDC is significantly inhibited in vitro and in vivo by clinically u...

The present common view about GRB origin is related to cosmology, what is based on statistical analysis, and on measurements of the redshifts in the GRB optical afterglows of long GRB. No correlation is found between redshifts, GRB spectrum, and total GRB fluence. Comparison of KONUS and BATSE data about statistics and hard X-ray lines is done, and some differences are noted. Hard gamma-ray aft...

BACKGROUND Granzyme B (GrB) is a serine protease, traditionally known as expressed by cytotoxic lymphocytes to induce target cell apoptosis. However, it is emerging that GrB, being also produced by a variety of normal and neoplastic cells and potentially acting on multiple targets, might represent a powerful regulator of a wide range of fundamental biological processes. We have previously shown...

هدف: رشته مهندسی عمران از رشته‌های پرطرفدار می‌باشد که دانش‌آموختگان آن مسئولیت‌های زیادی در سازندگی و آبادانی کشور دارند بر همین اساس ضرورت دارد برنامه‌ درسی منجر به نتایج مطلوب گردد. راستا، هدف پژوهش حاضر، شناسایی برنامه کارشناسی ارزیابی وضعیت موجود ‌درسی این بعد بوده است.مواد روش‌ها: رویکرد تحقیق، ترکیبی اکتشافی متوالی نوع ابزارسازی است. روش تحقیق کیفی مطالعه، پدیدارشناسی بخش کمی پیمایشی حاض...

An Eγ,jet ∝ E ′ p 1.5 relationship with a small scatter for current γ-ray burst (GRB) data was recently reported, where Eγ,jet is the beaming-corrected γ-ray energy and E ′ p is the νFν peak energy in the local observer frame. By considering this relationship for a sample of 12 GRBs with known redshift, peak energy, and break time of afterglow light curves, we constrain the mass density of the ...

A few tight correlations linking several properties of gamma–ray bursts (GRBs), namely the spectral peak energy, the total radiated energy, and the afterglow break time, have been discovered with pre-Swift GRBs. They were used to constrain the cosmological parameters together with type-Ia supernovae. However, the tightness of these correlations is a challenge to GRB models. We explore the effec...

In this paper, utilization of clustering algorithms for data fusion in decision level is proposed. The results of automatic isolated word recognition, which are derived from speech spectrograph and Linear Predictive Coding (LPC) analysis, are combined with each other by using fuzzy clustering algorithms, especially fuzzy k-means and fuzzy vector quantization. Experimental results show that the ...

The Large Aperture GRB Observatory (LAGO) is aiming at the detection of the high energy (around 100 GeV) component of Gamma Ray Bursts, using the single particle technique in arrays of Water Cherenkov Detectors (WCD) in high mountain sites (Chacaltaya, Bolivia, 5300 m a.s.l., Pico Espejo, Venezuela, 4750 m a.s.l., Sierra Negra, Mexico, 4650 m a.s.l). WCD at high altitude offer a unique possibil...

Aims. The behavior of the dark energy equation of state (EOS) is crucial in distinguishing different cosmological models. With a model independent approach, we constrain the possible evolution of the dark energy EOS. Methods. Gamma-ray bursts (GRBs) of redshifts up to z > 6 are used, in addition to type Ia supernovae (SNe Ia). We separate the redshifts into 4 bins and assume a constant EOS para...