نتایج جستجو برای: آنزیم gpx1

تعداد نتایج: 12135  

2016
Chao Luo Xiao-Teng Cai Jin Du Tao-Lan Zhao Peng-Fei Wang Ping-Xia Zhao Rui Liu Qi Xie Xiao-Feng Cao Cheng-Bin Xiang

Oxidative stress is unavoidable for aerobic organisms. When abiotic and biotic stresses are encountered, oxidative damage could occur in cells. To avoid this damage, defense mechanisms must be timely and efficiently modulated. While the response to oxidative stress has been extensively studied in plants, little is known about how the activated response is switched off when oxidative stress is d...

Journal: :Molecular carcinogenesis 2002
Ji-Qin Yang Garry R Buettner Frederick E Domann Qiang Li John F Engelhardt Christine Darby Weydert Larry W Oberley

The ras proto-oncogene is frequently mutated in human tumors and functions to constitutively stimulate signal transduction cascades, resulting in unchecked proliferation and malignant transformation. In certain cells, superoxide functions as a signal-transduction messenger, mediating the downstream effects of ras and rac. We demonstrated previously that v-Ha-ras-transfected rat kidney epithelia...

2017
Malgorzata Mrowicka Jerzy Mrowicki Michal Mik Radoslaw Wojtczak Lukasz Dziki Adam Dziki Ireneusz Majsterek

Purpose The main aim of this study was investigate the association between the genetic polymorphism of antioxidant enzyme genes: SOD1, CAT and GSHPX1 and the risk of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis in the Polish population. Methods A total of 445 subjects including 200 patients with IBD and 245 controls were allowed in this study. We determin...

2017
C Morén Í González-Casacuberta J Navarro-Otano D Juárez-Flores D Vilas G Garrabou J C Milisenda C Pont-Sunyer M Catalán-García M Guitart-Mampel E Tobías F Cardellach F Valldeoriola A Iranzo E Tolosa

OBJECTIVE To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson's disease (PD) subjects. METHODS Colonic biopsies from 7 iRBD subjects, 9 subjects with clinically diagnosed PD, and 9 healthy controls were homogenized in 5% w/v mannitol. Citrate synthase (CS) and complex I (CI) were analyzed spectrophot...

Journal: :Metallomics : integrated biometal science 2015
J Martitz N-P Becker K Renko M Stoedter S Hybsier L Schomburg

Sepsis is a severe inflammatory disease resulting in excessive production of pro-inflammatory cytokines including interleukin-6 (IL-6), causing oxidative stress, tissue damage and organ dysfunction. Health benefits have been observed upon selenium (Se) supplementation in severe sepsis. Selenium is incorporated into selenoproteins implicated in anti-oxidative defence, thyroid hormone metabolism ...

2010
Ana L. Miranda-Vilela Arthur K. Akimoto Penha C. Z. Alves Luiz C. S. Pereira Maria N. Klautau-Guimarães Cesar K. Grisolia

Physical training induces beneficial adaptation, whereas exhaustive exercises increase reactive oxygen-species generation, thereby causing oxidative damage in plasma and erythrocytes, fractions susceptible to lipid peroxidation. Pequi (Caryocar brasiliense Camb.) is a Brazilian Cerrado fruit containing a carotenoid-rich oil. The aim was to investigate the effects of pequi-oil on exercise-induce...

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