Various streptomyces strains [Streptomyces lividans 66, Streptomyces vinaceus, and Strepotmyces coelicolor A3 (2)] acquired the ability to utilize crystalline cellulose (Avicel) after transformation with a multicopy vector containing the cel-1 gene from Streptomyces reticuli. The expression level in these hosts was two to three times lower than in S. reticuli, indicating the absence of positive...

In chronic myelogenous (CML) and chronic eosinophilic leukemia (CEL), neoplastic cells spread via the circulation into various extramedullary organs. As E- and P-selectin constitute the starting point for the leucocyte adhesion/invasion cascade, and CEL and CML cells share many properties with normal granulocytes, we investigated the role of these selectins in CEL and CML cell expansion and org...

BACKGROUND An abnormal increase of contrast-enhancing lesion (CEL) counts on frequent MRIs is interpreted as a signal of potential worsening in multiple sclerosis (MS) clinical trials. We demonstrate the utility of the MR personalized activity index (MR-pax) to identify such increases. METHODS We analyzed a previous Phase II study in relapsing patients (n = 167) with MRIs at screening, baseli...

Chimeric antigen receptor (CAR) T cell therapies have demonstrated good clinical responses in populations that historically been difficult to treat; however, they are associated with potentially severe adverse events, including CRS and NEs. An economic model was created estimate total weighted costs of NEs for 2L treatment transplant-eligible relapsed/refractory large B-cell non-Hodgkin lymphom...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction The study aimed to identify cardiovascular magnetic resonance (CMR) imaging parameters representative Ebstein's Anomaly (EA) anatomical and clinical severity. Materials Methods Consecutive CMR patients with EA referred our Center, were evaluated retrospectively. Displacement index (DI) was defined as the distance betw...