Introduction: Chorioretinal coloboma (CRC) results from abnormal closure of the embryonic fissure. Choroidal neovascularization (CNV) is a rare complication that associated with choroid. VEGF an important factor in development CNV.
 Case Report: A 52-year-old woman gradual blurred vision left eye since 4 months ago. Right was already she child uncorrected visual acuity (UCVA) 0.5/60. Her r...

Human bone marrow derived mesenchymal stem cells (HBMSCs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. In this study, the differentiation of hBMSCs into endothelial like-cells was induced in presence of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1). The differentiated endothelial cells were exam...

Among numerical techniques used to facilitate the analysis of biochemical reactions, we can use method moments directly approximate statistics such as mean numbers molecules. The is computationally viable in time and memory, compared solving chemical master equation (CME) which notoriously expensive. In this study, apply a system with constant rate representing vascular endothelial growth facto...

background: oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. the role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. vascular endothelial growth factor (vegf) is an important regulator of angiogenesis. we aimed to evaluate the serum level of vegf in patients with oral lichen planus compared with normal in...

preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. early diagnosis and management of disease could reduce its potential side effects. the vascular endothelial growth factor (vegf) family including vegf-a is the most potent endothelial growth factor which induces angiogenesis and endothelial cel...

diabetic macular edema (dme) is an important cause of blindness in the working population and is currently challenging to treat. current interventions include focal laser or intravitreal injections. this article outlines a new treatment protocol based on the concept that peripheral ischemia is the introduction to angiogenesis, that will ultimately gather its momentum at the fovea. performing ex...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

background:diabetic retinopathy (dr) is a sight-threatening microvascular complication of diabetes in which the vascular endothelium is damaged due to oxidative stress and inflammation, and vitreous vegf concentration becomes elevated. the aim of the present study was to assess the association of dr with genetic variations of the mnsod, a major antioxidant enzyme, and vegf, an important mediato...

(PVR), macular degeneration, and retinitis pigmentosa (RP), can lead to blindness without timely treatment. Vascular endothelial growth factor (VEGF) has been identified as a key promoting vascular leakage angiogenesis, making neutralization of VEGF the first-line therapy for ischemic retinopathies such DR retinal occlusions. However, not all patients with these respond anti-VEGF therapy, neces...