نتایج جستجو برای: آنالیز in silico

تعداد نتایج: 17016896  

Journal: :Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2010
L Geris R Schugart H Van Oosterwyck

Wound and bone fracture healing are natural repair processes initiated by trauma. Over the last decade, many mathematical models have been established to investigate the healing processes in silico, in addition to ongoing experimental work. In recent days, the focus of the mathematical models has shifted from simulation of the healing process towards simulation of the impaired healing process a...

Journal: :European journal of medicinal chemistry 2012
Oscar P J van Linden Carine Farenc Willem H Zoutman Liesbeth Hameetman Maikel Wijtmans Rob Leurs Cornelis P Tensen Gregg Siegal Iwan J P de Esch

The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially available compounds was subjected to an in silico screening procedure which was focused on finding novel, EPHA4 hinge binding fragments. This...

Journal: :Advanced drug delivery reviews 2015
Mark Hewitt Claire M Ellison Mark T D Cronin Manuel Pastor Thomas Steger-Hartmann Jordi Munoz-Muriendas Francois Pognan Judith C Madden

The use of in silico tools within the drug development process to predict a wide range of properties including absorption, distribution, metabolism, elimination and toxicity has become increasingly important due to changes in legislation and both ethical and economic drivers to reduce animal testing. Whilst in silico tools have been used for decades there remains reluctance to accept prediction...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه لرستان 1390

زیردیفرانسیل و آنالیز تقریبی روی فضاهای باناخ در این رساله با مطالعه ی دقیق مقاله proximal analysis in reflexive smooth banach spaces یک مخروط نرمال تقریبی در فضاهای باناخ بازتابی و هموار برحسب عملگر تصویر تعمیم یافته معرفی و مطالعه می کنیم. همچنین دو نوع جدید از زیر دیفرانسیل های تعمیم یافته در فضاهای باناخ بازتابی و هموار

2013
Heidi Bialk Craig Llewellyn Alison Kretser Richard Canady Richard Lane Jeffrey Barach

This workshop aimed to elucidate the contribution of computational and emerging in vitro methods to the weight of evidence used by risk assessors in food safety assessments. The following issues were discussed: using in silico and high-throughput screening (HTS) data to confirm the safety of approved food ingredients, applying in silico and HTS data in the process of assessing the safety of a n...

Journal: :Nature Biotechnology 1997

Journal: :Genetics and Molecular Biology 2005

Journal: :International Journal of Medical and Biomedical Studies 2022


 Tuberculosis (TB) is a highly contagious disease, and the increased mortality rate continues to be cause for concern. Although anti-tuberculosis drugs are available, it still affects mankind, causing millions of deaths each year. By integrating biological data on gene sequences, expressions, protein structures, drug target prioritization. The number cheminformatics databases small molecu...

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