Lactoferrin, a glycoprotein present in neutrophils and exocrine secretions, plays important roles in host defense. Administration of bovine lactoferrin has been reported to modulate various neutrophil functions. We found a mixed-breed male dog with novel familial neutrophil dysfunction. The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation. Antibiotics t...

AIMS β2-adrenergic stimulation causes beneficial effects on structure and function of regenerating muscles; thus, the β2-adrenoceptor may play an important role in the muscle regenerative process. Here, we investigated the role of the β2 -adrenoceptor in skeletal muscle regeneration. METHODS Tibialis anterior (TA) muscles from β2-adrenoceptor knockout (β2 KO) mice were cryolesioned and analys...

1. Abstract 2. Introduction 3. Discussion 3.1. β2 integrin engagement induces activation of tyrosine kinases 3.1.1 Activation of src family tyrosine kinases 3.1.2. Activation of Syk 3.1.3. Activation of tyrosine kinases of the FAK family 3.2. Proteins that are tyrosine phosphorylated upon β2 integrin engagement in leukocytes 3.2.1. The docking protein Cbl 3.2.2. The guanine nucleotide exchange ...

Proof Fix a satisfying assignment a. Define the distance of r to a, denoted dist(r, a), as the number of coordinates where ri 6= ai (this is called Hamming distance). Let r = r, r, r, · · · be the assignments generated by the algorithm, and let di = dist(r , a). Note that as we only change one bit of the assignment, di+1 = di + ∆i where ∆i ∈ {−1, 1}. We claim that Pr[∆i = −1] ≥ 1/2. Once this i...

Background: Beta-2 glycoprotein I antibodies (B2-GPI Ab) are significant markers of thrombosis in otoimmune diseases. No literature has been found in Bcr Abl (-) MPNs to exclude the risk of hereditary thrombophilia and to investigate the association of B2-GPI Ab levels with thrombosis. This study aimed to investigate the relation between levels of B2-GPI Ab and thrombosis in BcrAbl (-) MPN with...

Antiphospholipid antibodies (aPLs) are a heterogeneous group of antibodies directed against phospholipids or protein/phospholipid complexes. Currently, aPLs are assessed using either "solid-phase" assays that identify anticardiolipin antibodies and anti-β2-glycoprotein I antibodies or "liquid-phase" assay that identifies lupus anticoagulant. However, in the last few years, "new" antigenic targe...