Estrogen receptor-alpha (ERα) is a key factor in the development of breast cancer in humans. The expression and activity of ERα is regulated by a multitude of intracellular and extracellular signals. Here we show a cross-talk between β-catenin and ERα in human breast cancer cells. Knockdown of β-catenin by RNAi resulted in significant reduction of ERα mRNA and/or protein levels in MCF-7, T-47D,...

The purpose of this study is to build the binary logit model of an airport pavement that could monitor the pavement condition in near real time using microwave remote sensing satellite, then the relationship between the international roughness index (IRI) of an airport and backscattering values from PALSAR images of the ALOS satellite was determined. Total 390 data were used in analysis. This m...

Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a scr...

The current study was undertaken to determine the 17-β Estradiol (E2) and Progesterone (P4) levels in different milk products some baby follow-on samples collected from retail markets Türkiye. For this purpose, a total of 50 8 product groups with fat levels, production technologies, series were analyzed for natural P4 E2 using commercial ELISA kit. highest level determined UHT whole (3%) (39.20...

A convenient homogeneous enzyme immunoassay for estradiol is described. Unlike heterogeneous immunoassays, which require time-consuming separation steps or expensive automated systems, homogeneous immunoassays, wherein all reagents are freely suspended in bulk solution, can be simple and fast without costly instrumentation. The key component of this assay system, an estradiol-reporter enzyme co...

Research aim: to investigate the proliferative status of endometrium in different morphotypes endometrial hyperplasia based upon identification key molecular markers cell cycle.Materials and methods. Endometrial samples taken from 137 women were investigated: 40 – normal (NE), 61 non-atypical (ЕH), 36 atypical (AHE). Expression gene cyclin D1, nuclear antigen Кі-67, glycoproteins Е-cadherin β-c...

OBJECTIVE 11β-Hydroxysteroid dehydrogenase type I (11βHSD1) regenerates active cortisol from inert cortisone in adipose tissue. Elevated adipose tissue 11βHSD1 activity is observed in obese humans and rodents, where it is linked to obesity and its metabolic consequences. Menopause is also associated with increased abdominal fat accumulation, suggesting that estrogen is also important in adipose...

Individuals diagnosed with Ulcerative Colitis (UC) often seek complementary lifestyle methods, such as diet and physical activity, to self-manage disease symptoms respond the psychosocial challenges of living chronic illness. The Energy Adjusted Dietary Inflammatory Index (E-DIITM) measures inflammatory potential one’s food intake has never been studied among UC population. This study aimed tes...

Background: Chronic inflammatory rheumatic diseases are risk factors of bone loss and fractures. Systemic sclerosis (SSc) has been recognized to be another potential joint disease that may affect tissue. Objectives: evaluate mineral density (BMD) low BMD in women with SSc. Methods: 173 women, among them 110 postmenopausal (median age 60[55,63] years) 63 premenopausal 35[31,44] years). was measu...

OBJECTIVES To assess the correlations between blood levels of sex steroid hormones and blood lipid profile or the degree of coronary artery stenosis in men with coronary artery disease (CAD). METHODS 111 men with stable CAD, aged 36-73 yrs, unselected for the coexisting clinical coronary risk factors were prospectively studied. Degree of coronary stenosis was assessed angiographically using d...