BACKGROUND: Ultraviolet B (UVB) radiation is the main factor causing aberrant melanin pigments leading to skin hyperpigmentation. Retinoic acid and hydroquinone are primary preference for whitening agents in preventing However, these treatments could induce slight-to-severe irritation cancer. Mangosteen peel possesses α-mangostin, constituent of xanthones mangosteen that has potency as an anti-...

Ekstrak kulit manggis (Garcinia mangostana L.) mengandung xanthone dengan senyawa utama alfa mangostin dan gamma-mangostin yang berfungsi sebagai antioksidan dalam melindungi mukosa lambung. Tujuan dari penelitian ini ingin mengetahui pengaruh pemberian ekstrak pelindung lambung tikus diinduksi asam asetilsalisilat (ASA). Penelitian menggunakan 24 ekor dibagi menjadi empat kelompok perlakuan te...

The TRPV3 calcium ion channel is vital for maintaining skin health and has been associated with various skin-related disorders. Since involved in the development of inflammation, inhibiting could be a potential treatment strategy. Alpha-mangostin isolated from Garcinia mangostana L. extract exhibits diverse positive effects on health; however, underlying mechanisms remain obscure. This study in...

SARS CoV-2 infection causes various clinical manifestations ranging from mild to severe. Acute RespiratoryDistress Syndrome (ARDS) is a severe complication of COVID-19 caused by activation the kallikreinkininsystem which produces bradykinin potent proinflammatory mediator. This research anin silico study aims determine potential active medicinal plant compounds in inhibiting thekallikrein-kinin...

The effects of optimization microwave-assisted extraction (MAE) and microencapsulation on the total xanthone content (TXC), phenolic (TPC), antioxidant activity mangosteen rind extract were studied. Response surface methodology (RSM) was employed with Box-Behnken design to generate fifteen responses by incorporating three independent variables, namely soaking time, solvent-to-feed (S/F) ratio t...