OBJECTIVE It remains unclear whether very early onset psychosis (VEOP; ≤12years of age) and early onset psychosis (EOP; onset 13-17years of age) are homogeneous in their clinical presentation. We investigated the predictive value of age of psychosis onset for severity, functioning and demographic variation by: 1) comparing groups based on traditional cut-offs for age of psychosis onset, and 2) ...

Neurocognitive decline has been observed in patients with psychosis as well as attenuated psychosis syndrome (APS). We tested the hypothesis that APS increases dependence on neurocognition during the interpretation of others' mental states and that a combination index of Theory of Mind (ToM) and neurocognition improves the predictive accuracy of psychosis conversion. A sample of 83 APS individu...

OBJECTIVES Caring for demented people has been associated with negative effect on caregiver health. One or more severe stress factors can precipitate brief reactive psychosis. METHODS A 59-year-old Caucasian married woman with no prior psychosis has been caring for her severely demented husband for more than 3 years. She was treated for anxiety disorder and reaction to severe stress in our cl...

Previous work on chronic psychosis patients has suggested that low self-reflectiveness and overconfidence in judgments may be associated with delusions. In the present study we evaluated whether this extends to a first-episode psychosis sample. Thirteen actively delusional and 53 non-delusional participants with a first-episode psychosis completed the Beck Cognitive Insight Scale. Relative to n...

The role of stress in precipitating the onset and relapse of psychosis has been now widely recognised. Over the past decade, the major challenge of research in this field has been to elucidate the biological mechanisms involved in the interaction between stress and psychosis onset. Obvious focus of this research has been the study of biological systems involved in the stress response. I will he...

BACKGROUND Controversy remains as to whether cannabis acts as a causal risk factor for schizophrenia or other functional psychotic illnesses. AIMS To examine critically the evidence that cannabis causes psychosis using established criteria of causality. METHOD We identified five studies that included a well-defined sample drawn from population-based registers or cohorts and used prospective...

This paper describes how participatory design was employed in the of an automated Virtual Reality (VR) psychological therapy (gameChange), putting people with lived experience psychosis at heart process. Solutions to complex challenges invariably need include expertise and ideas specialists from a broad variety disciplines experiences. The gameChange relied on insights clinical psychologists, p...

enlargement andreduced corticalvolume arecorrelatesofchronic schizophrenia.We investigatedwhether genetic risk for psychosis is related to differences in foetal brain development asmeasuredby prenatalultrasonography.Routine foetal cerebralmeasures at19^23 weeks of gestationwere comparedbetweenthe offspring of 35 womenwith a historyof psychosis and105 controlwomenmatched for gestational age.Over...

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INTRODUCTION Pre-psychotic and early psychotic characteristics are investigated in the high-risk (HR) populations for psychosis. There are two different approaches based either on hereditary factors (genetic high risk, G-HR) or on the clinically manifested symptoms (clinical high risk, C-HR). Common features are an increased risk for development of psychosis and similar cognitive as well as str...