نتایج جستجو برای: zolpidem
تعداد نتایج: 964 فیلتر نتایج به سال:
OBJECTIVES The recommended zolpidem starting dose was lowered in females (5 mg vs. 10 mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown. We hypothesized that such differences were caused by known sex-related variability in alcohol dehydrogenase (ADH) expression. METHODS Male, female, and castr...
AIMS To determine the prevalence of non-prescribed drug use among subjects suspected of drug-impaired driving with a psychoactive prescription drug, and to identify associated factors. METHODS Subjects investigated for drug-impaired driving in Sweden during 2006-2009 with a confirmed intake of diazepam, flunitrazepam, tramadol, zolpidem or zopiclone were identified using the Swedish Forensic ...
Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeting insomnia on locomotor coordination and ethanol interaction using DORAs and gamma-aminobutyric acid (GABA)-A receptor modulators of distinct chem...
Two case reports of adverse reactions to Zolpidem are described. In both cases, the reaction was to a dosage oflOmg occurring about 15 minutes after intake of the drug.
No início de 2020 a Organização Mundial Saúde (OMS) definiu Covid-19 como uma doença pandêmica e, desde então foram criados diversos protocolos preventivos propagação do vírus incluindo o isolamento social, algo que, somado todas as incertezas que cercavam novo cenário mundial resultou em um aumento sofrimento psicológico e consequentemente uso substâncias psicoativas. Brasil, comercialização d...
Zolpidem (trade name Ambien) has attracted much interest as a sleep-inducing agent and also in research. Attention has been centered mainly on receptor binding and electrochemistry in the central nervous system which are briefly addressed herein. A novel integrated approach to mode of action is presented. The pathways to be discussed involve basicity, reduction potential, electrostatics, cell s...
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