Kidneys play a key role in zinc balance. The portion of Zn(II) that enters the glomerular filtrate is efficiently reabsorbed along the nephron through a mechanism yet to be identified. We used the Zn(II)-specific fluorophore Zinquin to visualize intracellular Zn(II) accumulated in the kidney epithelium and compared it with the intracellular localization of the vesicular zinc transporter ZnT4 bo...

The facB gene is required for acetate induction of acetamidase (amdS) and the acetate utilization enzymes acetyl-CoA synthase (facA), isocitrate lyase (acuD) and malate synthase (acuE) in Aspergillus nidulans. The facB gene encodes a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain which is shown to be required for DNA binding. In vitro DNA-bindin...

The DNA binding domain of the transcription factor LAC9 contains 6 cysteine residues with spacing in the primary peptide sequence identical to that found in the DNA binding domain of the GAL4 transcription factor. In GAL4, the CysX&ysX&ysX&ysX&ysX&ys motif has been shown to form a Zn(I&Cyss binuclear cluster (Pan, T. and Coleman, J. E. (1990) Proc. N&Z. Acud. Sci. U. S. A. 87, 2077-2081), repre...

The zinc(II) complex with NOTA [2,2',2''-(1,4,7-triazanonane-1,4,7-triyl)triacetate] has previously been synthesized and studied in solution, but was not isolated. The corresponding title Zn(II) complex penta-sodium(I) bis-{[2,2',2''-(1,4,7-triazanonane-1,4,7-triyl)triacetato]zinc(II)} tris-(perchlorate) methanol solvate, Na(5)[Zn(C(12)H(18)N(3)O(6))](2)(ClO(4))(3)·CH(3)OH, was crystallized as ...

Thermal Bergman cyclization of Pt(II) dialkynylporphyrins reveals a marked reduction in the cyclization temperature relative to the free base and Zn(II) derivatives. In contrast, photogenerated (3)ππ* population produces no detectable Bergman photocyclization, suggesting that the photoreactivities of the related free base and Zn(II) derivatives occurs via the (1)ππ* state.

A novel mixed-ligand zinc(II) complex with iminodiacetato(2-) (IDA) and adenine (AdeH) ligands has been obtained. Its crystal consists of octahedral molecules [Zn(IDA)(AdeH)(H2O)2] where the selective Zn–N9(AdeH) bond, involving the most basic N(AdeH) donor atom, occupies the trans position versus the Zn–N(IDA) bond. The Zn(II)–N9(AdeH) binding mode seems to be rare enough in comparison to thos...

macrocyclic heterobinuclear zn(ii)–cu(ii) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. the ligands include similar n4o2 and dissimilar n(imine)3o2 and n(amine)3o2 coordination sites sharing two phenolic oxygen atoms. the six-coordination site comprises two pyridyl pendant arms on the amine nit...

In the title compound, [Zn(2)(C(8)H(7)N(3)OS)(2)(C(5)H(5)N)(2)], the Zn(2)O(2) ring has a flattened roof shape, with the roof angle equal to 10.10 (6)°. The thio-semicarbazones act as tridentate ligands to one Zn(II) atom, with the O atoms additionally in bridging positions to the second Zn(II) atom. Both Zn(II) atoms are five-coordinated; the coordination polyhedra are close to square pyramids...

The first use of methyl 2-pyridyl ketone oxime (mpkoH) in zinc(II)/lanthanide(III) chemistry leads to the [ZnLn(mpko)3(mpkoH)3](ClO4)2 and [ZnLn(NO3)2(mpko)3(mpkoH)] families of dinuclear Zn(II)Ln(III) complexes displaying blue-green, ligand-based photoluminescence; the Zn(II)Dy(III) compound shows field-induced relaxation of magnetization.