The purpose of this note is to posit and discuss the concept of "competitive inhibition potential" (CIP), which is an in vivo index of the ability of a competitive inhibitor to elevate plasma concentrations of drug substrates, when the competitive inhibitor is administered at its usual and customary dose.

Three pulse photon echo peak shift spectroscopy and transient grating measurements on Zn-substituted cytochrome c, Zn-tetraphenylporphyrin, and Zn-protoporphyrin IX are reported. The effects of protein conformation, axial ligation, and solvent are investigated. Numerical simulations of the peak shift and transient grating experiments are presented. The simulations employed recently derived opti...

Eight commercially available organic Zn products and reagent-grade ZnSO4 x 7H2O (Zn Sulf) were evaluated by polarographic analysis, and solubility in .1 M K2HPO4-KH2PO4 buffer (pH 5), .2 M HCl-KCl buffer (pH 2), and deionized water. Fractions from these solubility tests were evaluated by gel filtration chromatography for structural integrity. Degree of chelation was generally positively related...

Quantitative scaling into percent signal change is helpful to detect and eliminate “bad” results with abnormal extreme values. While cognitive effects give signal changes on the order of 1% (and larger in the visual and auditory cortices), signal variations of over 10% may arise from motion and other artifacts in the data. Thus, a quantitative check on measured effect size can be used to screen...

Understanding how nutrients accumulate and change throughout the developmental stages according to BBCH scale can be a very effective technique for developing fertilization programmes high-quality, marketable grape production. Accordingly, macro- micronutrient concentrations at different growth were analyzed two commercial cultivars, viz., “Anab-e-Shahi” “Perlette”, by using an extended scale. ...