Based on an elementary osmotic pump, controlled release systems of diclofenac sodium (DS) were designed to deliver the drug in a zero-order release pattern. Osmotic pump tablets containing 100 mg DS were prepared and coated with either semipermeable (SPM) or microporous (PM) membranes. The tablet coats were composed of hydrophobic triacetin (TA) or hydrophilic polyethylene glycol 400 (PEG 400) ...

RefereeToolbox is based on an interpretation of the fusion rules by means of Referee Functions (refer to 2). This approach implies a dissociation between the definition of the combination and its actual implementation, which is common to all referee-based combinations. As a result, RefereeToolbox is designed with the aim to be generic and evolutive. It is composed of three distinct classes of o...

This paper proposes a new perspective in the enhancement of the closed-loop tracking performance by using the first-order hold (FOH) sensing technique. Firstly, the literature review and fundamentals of the FOH are outlined. Secondly, the performance of the most commonly used zero-order hold (ZOH) and that of the FOH are compared. Lastly, the detailed implementation of the FOH on a pendulum tra...

Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 2...

The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO) was used in tablets prepared by direct compression. The amounts of both polym...

The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Indomethacin and hydroxypropylmethylcellulose were used as model drug and polymer, respectively, in PEG matrix system. The physical and drug release characteristics of developed matrix tablet were studied. This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 c...

Evaluated in this study were the effects of the two parameters, namely level of penetration enhancer and drug loading dose, on in vitro skin release of Caffeine and vitamin B5 and adhesion properties of drug in adhesive transdermal systems. In order to characterize in vitro drug release, a hydrodynamically Chien permeation system with rat abdominal skin was employed. Caffeine skin release rate ...

For increased analgesic effect, new composed tablets containing diclofenac sodium (DIC) with an addition of papaverine hydrochloride (PAP) were prepared to investigate the mechanism of release of the active substances from tablets with different excipients in eight different formulations. To detect the possible interactions between active substances and excipients differential scanning calorime...