PURPOSE To present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single surgeon. MATERIALS AND METHODS The charts of 48 children treated for testicular tumors from 1986 to 2010 were retrospectively reviewed. All patients underwent radical orchiectomy. The patients' ages, clinical presentations, histopathological find...

Cis-Diamminedichloroplatinum II (CDDP) has been recognized as one of the most active drugs against malignant tumours including ovarian cancer. However, CDDP is a toxic drug causing emesis, renal failure, hearing loss, neuropathy and anaemia. In view of these toxicities many investigators have attempted to develop new platinum analogues which retain anti-tumour activity with less toxicity. Among...

Some months ago there was published from this laboratory a brief preliminary report of a method whereby tumors could be cultivated in the yolk sacs of developing chick embryos (4). Neoplasms were first injected into the yolk sac with the idea that the tumor cells would die and disintegrate, thus releasing any virus that might be present. It was hoped that if such a release occurred the medium p...

Wnts are secreted signaling molecules implicated in various developmental processes and frizzled proteins are the receptors for these Wnt ligands. To investigate the physiological roles of frizzled proteins, we isolated and characterized a novel mouse frizzled gene Fzd5. Fzd5 mRNA was expressed in the yolk sac, eye and lung bud at 9.5 days post coitum. Fzd5 specifically synergized with Wnt2, Wn...