نتایج جستجو برای: yap gene

تعداد نتایج: 1145607  

2013
Chrysiis Michaloglou Waltraut Lehmann Typhaine Martin Clara Delaunay Andreas Hueber Louise Barys Honglin Niu Eric Billy Markus Wartmann Moriko Ito Christopher J. Wilson Mary Ellen Digan Andreas Bauer Hans Voshol Gerhard Christofori William R. Sellers Francesco Hofmann Tobias Schmelzle

The Hippo (Hpo) pathway is a novel signaling pathway that controls organ size in Drosophila and mammals and is deregulated in a variety of human cancers. It consists of a set of kinases that, through a number of phosphorylation events, inactivate YAP, a transcriptional co-activator that controls cellular proliferation and apoptosis. We have identified PTPN14 as a YAP-binding protein that negati...

2015
Liangliang He Wenyan Xu Ying Jing Ming Wu Shuwei Song Ying Cao Changlin Mei

The Hippo signaling pathway and its transcriptional co-activator Yap are known as essential regulators for cell proliferation and organ size. However, little is known about their roles in kidney development and ciliogenesis. We examined expression of Yap during zebrafish embryogenesis, and its transcripts were detected in pronephric duct, while Yap protein was found to be localized in the cytop...

2016
YONGXIA QIAO YUNXIA QIAN JIAYI WANG XUN TANG

Dysfunction of the yes-associated protein (YAP) signaling pathway has previously been associated with liver tumorigenesis. Recently, the membrane protein melanoma cell adhesion molecule (MCAM) was identified as a novel, hepatocellular carcinoma (HCC)-specific YAP target protein that promotes carcinogenesis in HCC. However, whether MCAM conversely regulates YAP remains unknown. The aim of the cu...

Journal: :Journal of cell science 2012
Robert N Judson Annie M Tremblay Paul Knopp Robert B White Roby Urcia Cosimo De Bari Peter S Zammit Fernando D Camargo Henning Wackerhage

Satellite cells are the resident stem cells of skeletal muscle. Mitotically quiescent in mature muscle, they can be activated to proliferate and generate myoblasts to supply further myonuclei to hypertrophying or regenerating muscle fibres, or self-renew to maintain the resident stem cell pool. Here, we identify the transcriptional co-factor Yap as a novel regulator of satellite cell fate decis...

2015
Megan L. Finch Adam M. Passman Robyn P. Strauss George C. Yeoh Bernard A. Callus

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation of the Hippo pathway restricts YAP nuclear entry via its phosphorylation by Lats kinases and consequent cytoplasmic retention bound to 14-3-3 prote...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
Kai Zhao Chengyong Shen Yisheng Lu Zhihui Huang Lei Li Christopher D Rand Jinxiu Pan Xiang-Dong Sun Zhibing Tan Hongsheng Wang Guanglin Xing Yu Cao Guoqing Hu Jiliang Zhou Wen-Cheng Xiong Lin Mei

Yes-associated protein (Yap) is a major effector of the Hippo pathway that regulates cell proliferation and differentiation during development and restricts tissue growth in adult animals. However, its role in synapse formation remains poorly understood. In this study, we characterized Yap's role in the formation of the neuromuscular junction (NMJ). In HSA-Yap-/- mice where Yap was mutated spec...

2013
Marilyn Gordon Mohamed El-Kalla Yuewen Zhao Yahya Fiteih Jennifer Law Natalia Volodko Anwar Mohamed Ayman O. S. El-Kadi Lei Liu Jeff Odenbach Aducio Thiesen Christina Onyskiw Haya Abu Ghazaleh Jikyoung Park Sean Bong Lee Victor C. Yu Carlos Fernandez-Patron R. Todd Alexander Eytan Wine Shairaz Baksh

Ras association domain family protein 1A (RASSF1A) is a tumor suppressor gene silenced in cancer. Here we report that RASSF1A is a novel regulator of intestinal inflammation as Rassf1a(+/-) , Rassf1a(-/-) and an intestinal epithelial cell specific knockout mouse (Rassf1a (IEC-KO) ) rapidly became sick following dextran sulphate sodium (DSS) administration, a chemical inducer of colitis. Rassf1a...

2013
Hiu-Fung Yuen Cian M. McCrudden Yu-Han Huang Jill M. Tham Xiaoqian Zhang Qi Zeng Shu-Dong Zhang WanJin Hong

The Hippo pathway restricts the activity of transcriptional coactivators TAZ (WWTR1) and YAP. TAZ and YAP are reported to be overexpressed in various cancers, however, their prognostic significance in colorectal cancers remains unstudied. The expression levels of TAZ and YAP, and their downstream transcriptional targets, AXL and CTGF, were extracted from two independent colon cancer patient dat...

Journal: :Neuro-oncology 2014
Alizée Boin Anne Couvelard Christophe Couderc Isabel Brito Dan Filipescu Michel Kalamarides Pierre Bedossa Leanne De Koning Carine Danelsky Thierry Dubois Philippe Hupé Daniel Louvard Dominique Lallemand

BACKGROUND Inactivation of the NF2 gene predisposes to neurofibromatosis type II and the development of schwannomas. In vitro studies have shown that loss of NF2 leads to the induction of mitogenic signaling mediated by receptor tyrosine kinases (RTKs), MAP kinase, AKT, or Hippo pathways. The goal of our study was to evaluate the expression and activity of these signaling pathways in human schw...

2016
Zahid Nawaz Vikas Patil Anjali Arora Alangar S. Hegde Arimappamagan Arivazhagan Vani Santosh Kumaravel Somasundaram

Glioblastomas (GBM) are the most malignant form of astrocytomas which are difficult to treat and portend a grave clinical course and poor prognosis. In this study, we identified Chromobox homolog 7 (Cbx7), a member of Polycomb Repressive Complex 1 (PRC1), as a downregulated gene in GBM owing to its promoter hypermethylation. Bisulphite sequencing and methylation inhibitor treatment established ...

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