Using an airtight Y maze and a new method to induce peripheral anosmia in ferrets, we assessed the contribution of conspecific odors, either alone or in combination with visual and auditory signals, to heterosexual partner preference. Sexually naive ferrets were gonadectomized and treated with sex steroids, after which their nares were either bilaterally occluded using dental impression materia...

BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. METHODS Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...

Progressive cognitive decline is one of the hallmark symptoms of Alzheimer’s disease (AD) which can be modeled by β-amyloid injection into specific regions of brain. Since epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether EGCG administration protects against β-am...

Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. Due to the anti-diabetic and antioxidant activity of pelargonidin (PG), this research study was conducted to evaluate the efficacy of chronic oral PG on alleviating learning and memory disturbance in streptozotocin-diabetic rats. Male Wistar rats were divided into...

Alzheimer's disease (AD) is a complex neurodegenerative disorder with a progressive template leading to neural damage as well as cognitive and memory deficit. The present study designed to investigate the neuroprotective effects of Centella Asiatica (CA) in STZ-induced rat model of memory impairment and neuronal damage. ICV infusion of STZ (3 mg/kg) or saline (as vehicle) were performed on days...

Fipronil is a phenylpyrazole insecticide that widely used as pesticide and veterinary drug, although studies suggest it could be toxic to mammals. The objectives of this study were examine the pharmacokinetic profile fipronil in mice, dogs, cats, evaluate its effects on emotional cognitive behaviors dogs cats using data obtained from mice. assessment vivo kinetics was conducted mice dogs. We al...

The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2,...

The effect of α-asarone on impairment of cognitive performance caused by amnesic drug scopolamine was investigated. Treatment with α-asarone attenuated scopolamine-induced cognitive deficits as evaluated by passive avoidance and Y-maze test. Administration of α-asarone for 15 d improved memory and cognitive function as indicated by an increase in transfer latency time and spontaneous alternatio...