نتایج جستجو برای: xenotransplantation
تعداد نتایج: 1602 فیلتر نتایج به سال:
Rejections caused by xenotransplantation Transplantation between two different species may give rise to two types of graft rejection. Between so-called discordant species a hyperacute rejection (HAR) occurs within minutes or hours. In so-called concordant species this type of rejection does not occur, but over days a delayed xenograft rejection (DXG) (6) will occur. In all transplanted organs, ...
In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate immunity, the mechanisms of engraftment should be the same as those that permit the chimerism-dependent immunologic confrontation and resolution ...
Based on recommendations of the Norwegian Government, the Storting decided a preliminary prohibition against any medical treatment of humans with the use of biological material from animals in 1999. This moratorium should be in effect until 01.01.2003. During this time the issue of xenotransplantation, with its many problems and controversies, should be thoroughly elucidated and debated. A xeno...
Xenotransplantation of porcine tissues has the potential to treat a wide variety of major health problems including organ failure and diabetes. Balanced against the potential benefits of xenotransplantation, however, is the risk of human infection with a porcine microorganism. In particular, the transmission of porcine endogenous retrovirus (PERV) is a major concern [Chapman, L. E. & Bloom, E. ...
To the Editor: I read with considerable interest Robert E. Michler’s commentary on xenotransplantation (1). From my point of view, that of a basic virologist, the dilemma is not to know in what “foreseeable future, clinical xenotransplantation may achieve its targeted goal of extended graft survival,” but what deadly emerging infectious disease, most probably viral in nature, would arise in a r...
Pigs have been considered as donors for xenotransplantation in the replacement of human organs and tissues. However, porcine endogenous retroviruses (PERVs) might transmit new infectious disease to humans during xenotransplantation. To investigate PERV integration sites, 45 PERV-positive BAC clones, including 12 PERV-A, 16 PERV-B, and 17 PERV-C clones, were identified from the NIH miniature pig...
In this article, we examine the advanced clinical development of bioartificial organs and describe the challenges to implementing such systems into patient care. The case for bioartificial organs is evident: they are meant to reduce patient morbidity and mortality caused by the persistent shortage of organs available for allotransplantation. The widespread introduction and adoption of bioengine...
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