نتایج جستجو برای: xdr

تعداد نتایج: 1279  

2018
Onno W. Akkerman Floris Grasmeijer Wiel C.M. de Lange Huib A.M. Kerstjens Gerard de Vries Mathieu S. Bolhuis Jan-Willem Alffenaar Henderik W. Frijlink Grace Smith Roger Gajraj Rina de Zwaan Paul Hagedoorn Martin Dedicoat Dick van Soolingen Tjip S. van der Werf

Extensively drug-resistant (XDR) tuberculosis (TB) is defined by resistance to isoniazid, rifampicin, any fluoroquinolone and at least one of the three second line injectable drugs, such as amikacin. Drug toxicity and duration impair adherence to treatment and outcome is rather poor [1]. We report on a particularly challenging XDR-TB patient with persistent non-adherence to treatment and an exc...

2014
Rupesh V Chikhale Amit M Pant Sunil S Menghani Pramod B Khedekar

Background The emerging multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (MTB) infection is increasing with greater complexity, estimated 220000-400000 tuberculosis cases emerged in 2011 globally. A number of lead compounds have been developed for treatment of MDR and XDR TB, but no new chemical entity has emerged for clinical use. Recently DprE1 and AHA...

Journal: :The European respiratory journal 2011
I R Lake N R Jones L Bradshaw I Abubakar

REFERENCES 1 World Health Organization. Multidrug and Extensively DrugResistant TB (M/XDR-TB). 2010 Global Report on Surveillance and Response. WHO/HTM/TB/2010.3. Geneva, World Health Organization, 2010. 2 Sotgiu G, Ferrara G, Matteelli A, et al. Epidemiology and clinical management of XDR-TB: a systematic review by TBNET. Eur Respir J 2009; 33: 871–881. 3 Migliori GB, Loddenkemper R, Blasi F, ...

Journal: :Antimicrobial agents and chemotherapy 2013
David J Farrell Robert K Flamm Helio S Sader Ronald N Jones

Ceftolozane/tazobactam, a novel antimicrobial agent with activity against Pseudomonas aeruginosa (including drug-resistant strains) and other common Gram-negative pathogens (including most extended-spectrum-β-lactamase [ESBL]-producing Enterobacteriaceae strains), and comparator agents were susceptibility tested by a reference broth microdilution method against 7,071 Enterobacteriaceae and 1,97...

Journal: :Kekkaku : [Tuberculosis] 2007
Yuko Kazumi Nobunori Itagaki Masako Ohmori Masako Wada Hitoshi Hoshino Satoshi Mitarai Isamu Sugawara Nobukatsu Ishikawa Toru Mori

PURPOSE To observe the frequency of MDR-TB/XDR-TB strains isolated from chronic pulmonary tuberculosis patients in Japan. OBJECT Ad hoc National Tuberculosis Survey 2000 on frequency of MDR-TB and XDR-TB strains. MATERIALS AND METHOD Four hundred and thirty four clinical isolates were collected by the Ad hoc National Tuberculosis Survey 2000, the drug susceptibility testings (proportion met...

Journal: :Acta medica portuguesa 2012
Leonard Amaral

Globally, tuberculosis infections continue to increase their resistance to antibiotics. Multidrug resistant tuberculosis infections (MDR TB) have progressed to extensively drug resistance status (XDR TB) and the latter have evolved in some parts of the world to totally drug resistant (TDR TB) infections. MDR TB is difficult to treat successfully, and when therapy is ineffective, a single case c...

Journal: :The Medical journal of Malaysia 2015
S R A Muhammad Redzwan A P Ralph K K Sivaraman Kannan T William

Clinical experience with extensively Drug Resistant tuberculosis (XDR-TB) has not been reported in Malaysia before. We describe the clinical characteristics, risk factors, progress and therapeutic regimen for a healthcare worker with XDR-TB, who had failed therapy for multidrug resistant TB (MDR TB) in our institution. This case illustrates the risk of TB among healthcare workers in high TB-bur...

2017
Risara Jaksuwan Prasit Tharavichikul Jayanton Patumanond Charoen Chuchottaworn Sakarin Chanwong Saijai Smithtikarn Jongkolnee Settakorn

BACKGROUND Multidrug/extensively drug-resistant tuberculosis (M/XDR-TB) is a major public health problem, and early detection is important for preventing its spread. This study aimed to demonstrate the distribution of genetic site mutation associated with drug resistance in M/XDR-TB in the northern Thai population. METHODS Thirty-four clinical MTB isolates from M/XDR-TB patients in the upper ...

2010
Scott K Heysell Tania A Thomas Neel R Gandhi Anthony P Moll François J Eksteen Yacoob Coovadia Lynette Roux Palav Babaria Umesh Lalloo Gerald Friedland Sarita Shah

BACKGROUND The yield of mycobacterial blood cultures for multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR-TB) among drug-resistant TB suspects has not been described. METHODS We performed a retrospective, cross-sectional analysis to determine the yield of mycobacterial blood cultures for MDR-TB and XDR-TB among patients suspected of drug-resistant TB from rural South...

Journal: :Antimicrobial agents and chemotherapy 2010
Alka Khanna V Samuel Raj Bansidhar Tarai Ruchi Sood Pawan Kumar Pareek Dilip J Upadhyay Pawan Sharma Ashok Rattan Kulvinder Singh Saini Harpal Singh

We screened 194 Mycobacterium tuberculosis strains isolated from tuberculosis (TB) patients in Delhi and neighboring regions in India to identify the prevalence of extensive drug resistance (XDR) in clinical isolates. Among these, 104 isolates were found to be multidrug resistant (MDR), and 6 were identified as XDR isolates, which was later confirmed by antimicrobial susceptibility testing agai...

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