The dose and timing of antimicrobial agents given for surgical wound prophylaxis should be based on the concentration-time profile of the drug in tissue at the site of contamination. However, concentrations of antimicrobial agents in surgical wounds are difficult to determine accurately. Since a surgical wound is a unique extravascular compartment with increased vascular permeability and a high...

AIMS This study investigated the effect of low-intensity cathodal direct current (CDC) of electrical stimulation (ES) on the release of hypoxic inducible factor-1α (HIF-1α), nitric oxide (NO), vascular endothelial growth factor (VEGF), and soluble VEGF receptor-2 (sVEGFR-2) in the wound fluid of ischemic diabetic foot ulcers (DFUs). METHODS This study was a randomized, single-blind, placebo-c...

UNLABELLED The development and subsequent deterioration of diabetic foot ulceration (DFU) is a common occurrence across all healthcare divides, concerning all patient groups, age, gender and social environments. It increases demand on clinical resources and creates unnecessary hardship for patients. Chronic DFU is challenging to prevent and notoriously difficult to manage owing to the complex n...

BACKGROUND Compression therapy is the most widely used treatment for venous leg ulcers and it was used in different forms for more than 400 years. Published healing rates of venous ulcers obtained with compression therapy vary widely from 40-95%. According to numerous studies, it has been suggested that the application of external pressure to the calf muscle raises the interstitial pressure res...

Warfare-related torso/abdominal wounds are often unique and complex and can pose a significant reconstructive challenge. The objective of this manuscript is to report the unique and successful management of a complex warfare-related abdominal wound. A dermal regenerate template in combination with negative pressure wound therapy was used to reconstitute lateral abdominal wall integrity after ra...

Introduction Wound dressings that adhere to the wound surface can disrupt the wound bed and destroy newly formed, healthy tissue on removal, resulting in a disturbed, rough surface. This often happens with simple gauze pad. To avoid conglutination with the wound, e.g. combined fleece compresses possess a micro-porous polyester foil or impregnated gauze is used. So far, it hasn’t been studied wh...

background: connective tissue attachment following periodontal regenerative surgery is directly related to the attachment of fibrin clot on to the root surface during early wound healing events. the adhesion of fibrin clot to the root surface affected by periodontal disease depends on the biologic acceptance of the root surface which can be accomplished by various root conditioning procedures d...

Exposure to stress can affect an organism's partitioning of resources among immune function and other organismal functions. However, measuring immune function is often difficult. Recent studies show that the rate of cutaneous wound healing in laboratory rodents is a simple, integrated measure of stress-sensitive immune function. We investigated the use of this technique in tree lizards to test ...