Growth inhibition by methotrexate (MTX) of a cultured mouse mammary carcinoma FM3A line and its mutants deficient in thymidine kinase and thymidylate synthetase was studied un der a variety of conditions. In medium containing 10 ¡IMthy midine, the thymidylate synthetase-deficient mutants were slightly more resistant to MTX than the wild-type line and the thymidine kinase-deficient mutant. The ...

â â  a great portion of precipitation in the south western iran falls in the snow formation. surface runoff produced from melting snow has an important role in the recharging ground water, surface and subsurface flows. rapid snowmelt can even cause flooding . since the snowmelt cannot be easily detected from optical satellite images, snow cover area (sca) is derived as an important hydrological...

Persistent, 10-km-scale gradients in climatological precipitation tied to topography are documented with a finescale rain and snow gauge network in the Matheny Ridge area of the Olympic Mountains of Washington State. Precipitation totals are 50% higher on top of an 800-m-high ridge relative to valleys on either side, 10 km distant. Operational fifth-generation Pennsylvania State University–NCAR...

Transplanted mouse leukemia is being utilized as a test object for agents now being used in clini cal treatment and as a screen for compounds which might conceivably be employed in the therapy of human leukemia (†̃2, 6, 7). The objective of the present study was to test the influence of certain folic acid antagonists on the course and develop ment of transplanted leukemia which originated in t...

Scientists strongly believe that, String theory is empowered with good mathematics and smartly fits gravity in unification program. Point to be noted by considering the Planck length as characteristic amplitude associated strings, advances its ideological representation. Very unfortunate thing even though, originally, was proposed for understanding ‘strong interaction’, 20 orders of magnitu...

Aniline and o-, m-, and /Moluidine, which are representative of aro matic amines in cigarette smoke, were identified and quantified in human urine. Smokers excreted 3.1 ±2.6 «¿g/24 h of aniline and 6.3 ±3.7 ¿ig/ 24 h of o-toluidine (n = 16). Nonsmokers excreted 2.8 ±2.5 Mg/24 h of aniline and 4.1 ±3.2 un; 24 h of o-toluidine (n = 12). Metaand /»toluidine were detected in the urine of 2 ...

Page 3. It is not entirely clear what causal model the authors have in mind, and specifically whether they consider smoking and air pollution as mediators or confounders of the association between SES and respiratory health. In paragraph two, page 1, they imply mediation (â##â#¦strongly influenced by SES..â##) but in paragraph three, confounding is implied (â##....competing factorsâ#¦â##). This...

/V-Succinimidyl 3-{tri-n-butylstannyl)benzoate (ATE) was evaluated for its utility in the radiohalogenation of monoclonal antibodies. The Hab'h fragment of monoclonal antibody OC 125 was labeled with '-"I using the ATE reagent and with '"I using a conventional electrophilic iodination method (lodogen). V-Sumnimidyl 3-[nsI]iodobenzoate was synthesized from ATE in >90% yield and purified using a ...

A newly established gastric carcinoma cell line (EPG85-257P) exhib ited a high sensitivity to mitoxantrone (DHAD) as determined by a monolayer proliferation assay. The concentration to inhibit cell growth to 50% of controls (IG»)was 0.0022 «¿g/ml culture medium. The cells were continuously incubated for more than 4 months in the presence of stepwise increased concentrations of DHAD, and the ...