Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability to GBE to help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated the influence of different concentrations of GBE on superoxide dismutase (SOD) and apoptosis of diabetic peripheral blood EPCs. Twenty-five diabetic patients without any vascula...

The confirmation of target expression in tissues is a prerequisite for molecular-targeted therapy. However, difficulties are sometimes associated with the production of appropriate antibodies against receptors. We herein developed a ligand derivative dye for the staining of receptors. The somatostatin receptor (sstr) was selected as the target and FITC-octreotate as the detective agent. We perf...

Women with a history of preeclampsia (PE) have an increased risk to develop cardiovascular and renal diseases later in life, but the mechanisms underlying this effect are unknown. In rats, we assessed whether placental ischemia results in long-term effects on the maternal cardiovascular and renal systems using the reduced uterine perfusion pressure (RUPP) model for PE. Sprague-Dawley rats recei...

Th e term “planta hortifuga“ refers to all cultivated plant species that have escaped from cultivation and grow spontaneously in diff erent natural, semi-natural or manmade habitats. List of “planta hortifuga” (Tab.1) consists of 120 taxa. Traits are given for each species: Raunkiaer’s life-form groups, taxonomic rank (family and species), geographical origin, use value, invaded habitat, invasi...

Broad spectrum therapeutic potential of curcumin is usually hampered by its photodegradation and low bioavailability. Present investigation was designed with an objective to develop transferrin-mediated solid lipid nanoparticles (Tf-C-SLN) resistant to the photostability and capable of enhancing the bioavailability by targeted drug delivery to elicit anticancer activity against SH-SY5Y neurobla...

Stem cell (SC) therapy for ischemic cardiomyopathy is hampered by poor survival of the implanted cells. Recently, SC-derived exosomes have been shown to facilitate cell proliferation and survival by transporting various proteins and non-coding RNAs (such as microRNAs and lncRNAs). In this study, miR-21 was highly enriched in exosomes derived from bone marrow mesenchymal stem cells (MSCs). Inter...

BACKGROUND/AIM Treatment of human non-small-cell lung cancer (NSCLC) often involves uses of multiple therapeutic strategies with different mechanisms of action. Here we found that resveratrol (RV) enhanced the anti-tumor effects of epidermal growth factor receptor (EGFR) inhibitor erlotinib in NSCLC cells. METHODS Cell viability was measured by MTT assay and clonogenicity assay. Western blot ...

Launching Part Two of this special section is a reminder, among many similar reminders, the relentless passage time and strange, distorted distance between beginning pandemic where we are now. Looking backward forward often feels equally dizzying to me, yet remains “constitutive dimension social reality” (Fabien 1983, 24). As ethnographers, attend human subjectivities embedded in place time. Th...

Apoptosis is increasingly recognized as an important factor in vascular remodelling and disease [I]. Platelet-derived growth factor-BB (PDGF-BB) is a potent mitogen in many cell types, including human vascular smooth muscle cells [2], and has been implicated in the vascular response to injury and atherogenesis [3]. Induction of apoptosis is known to be influenced by the presence of survival fac...

PURPOSE Benzyl alcohol (BA) is the preservative in triamcinolone acetonide (TA) suspensions, which are used in treating vitreoretinal diseases and during surgery. This paper investigates the molecular mechanisms and signaling pathways underlying BA toxicity in human retinal pigment epithelial (RPE) cells. METHODS Cultured human RPE cells from the ARPE-19 cell line were exposed to culture medi...