BACKGROUND Wilms' tumor is the commonest primary malignant renal tumor in childhood. Rarely, it may present in the adult age group. CASE PRESENTATION We report a 48-year-old male presenting with flank pain and haematuria. Abdominal ultrasound revealed a right renal mass measuring 11 x 10 cms, and a clinical diagnosis of renal cell carcinoma was made. Nephrectomy was performed, and a final dia...

The H19 gene, which localizes within a chromosomal region on human chromosome 11p15 that is commonly lost in Wilms tumor (WT), encodes an imprinted untranslated RNA. However, the biological significance of the H19 noncoding transcript remains unresolved because replacement of the RNA transcript with a neocassette has no obvious phenotypic effect. Here we show that the human H19 locus also encod...

Wilms tumor surgery requires meticulous planning and sophisticated surgical technique. Detailed anatomical knowledge can facilitate the uneventful performance of tumor nephrectomy and cannot be replaced by advanced and sophisticated imaging techniques. We can define two main goals for surgery: (1) exact staging as well as (2) safe and complete resection of tumor without spillage. This review ai...

Nephroblastoma (Wilms' tumor) is frequently associated with mortality in children. MicroRNAs (miRNAs) are important for tumor development serving as oncogenes or tumor suppressors. In the present study, miRNA‑590 (miR‑590) was identified to be upregulated in Wilms' tumor tissues compared with the normal adjacent tissues. Additionally, the levels of miR‑590 were consistent with their clinical st...

Nephroblastoma (Wilms tumor – WT) is the most common kidney among pediatric population, fifth malignant neoplasms and third solid tumors. The type of WT sporadic unilateral. occurs either as an isolated, nonsyndromic or syndromic one belonging to spectrum a variety genetic syndromes. Molecular testing should be considered in include multigene panel whole exome sequencing (WES); cases single-gen...

Like testicular cancer in adulthood, the Wilms' tumor or nephroblastoma in childhood is an example of a curable malignant disease. The review by Huszno et al. in this Journal gives an overview concerning diagnosis and treatment of adult Wilms' tumors [1]. This tumor entity was first described in 1814 by Rance and in 1899 Max Wilms, a German surgeon, described this tumor in detail [2]. Beckwith ...

Wilms' tumor is one of the most common malignant tumors observed in children, and its early diagnosis is important for late-stage treatment and prognosis. We previously screened and identified protein markers for Wilms' tumor; however, these markers lacked specificity, and some were associated with inflammation. In the current study, serum samples from children with Wilms' tumors were compared ...