BACKGROUND AND PURPOSE DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semia...

The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian Stroke Prevention Study (mean age 70, age range...

Early-treated phenylketonuria (PKU) is associated with a range of neuropsychological impairments. Proposed mechanisms for these impairments include dopamine depletion and white matter pathology. Neuroimaging studies demonstrate high-signal intensity in the periventricular white matter in most PKU patients, which can extend into subcortical and frontal regions in more severe cases. A review of h...

Methods for measurement of glyceraldehyde-P dehydrogenase, triose-P isomerase, fructose 1,6-diphosphate aldolase, and the DPN-linked and flavin-linked alpha-glycero-P dehydrogenases in small amounts of tissue have been worked out. These enzymes have been measured in ten tracts in rabbit central nervous system. The activities of all the enzymes measured, except the flavin-linked alpha-glycero-P ...

The segmentation of MRI scans of patients with white matter lesions (WML) is difficult because the MRI characteristics of white matter lesions are similar to those of grey matter. Intensity based statistical classification techniques misclassify some WML as grey matter and some grey matter as WML. We developed a fast elastic matching algorithm that warps a reference data set containing informat...

The resolution of present day computed tomography (CT) scanners routinely permits discrimination of gray from white matter with delineation of a gray-white matter interface. Superficially situated extraaxial masses usually preserve the gray-white interface and tend to compress and/or buckle adjacent edematous white matter. This does not occur with superficially situated intraaxial lesions and i...

The brain white matter is responsible for the transmission of electrical signals through the central nervous system. Lesions in the brain white matter, called white matter hyperintensity (WMH), can cause a significant functional deficit. WMH are commonly seen in normal aging, but also in a number of neurological and psychiatric disorders. We propose here an automatic method for WHM analysis in ...

In a patient whose Creutzfeldt-Jakob disease with congophilic kuru plaques that was proved at necropsy, the early brain CT showed low-density areas in the cerebral white matter before cortical atrophy and ventricular enlargement became apparent. Subsequently, there occurred diffuse white matter lucency and severe brain atrophy. At necropsy, there was severe white matter destruction which was mo...

BACKGROUND AND PURPOSE Diffusion-weighted imaging is a robust technique for evaluation of a variety of neurologic diseases affecting the brain, and might also have applications in the spinal cord. The purpose of this study was to determine the feasibility of obtaining in vivo diffusion-weighted images of the human spinal cord, to calculate normal apparent diffusion coefficient (ADC) values, and...

White matter structure declines with advancing age and has been associated with a decline in memory and executive processes in older adulthood. Yet, recent research suggests that higher physical activity and fitness levels may be associated with less white matter degeneration in late life, although the tract-specificity of this relationship is not well understood. In addition, these prior studi...