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introduction: the aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (nlr), platelet-to-lymphocyte ratio (plr), and mean platelet volume (mpv) in patients with recurrent aphthous stomatitis (ras).   materials and methods: eighty patients who were diagnosed with ras between january 2014 and january 2016 were included in this study. eighty age- and gender-matched healthy subject...

introduction: multiple sclerosis (ms) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. a potential therapeutic approach should possess several properties: prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (opcs) into mature oligodendrocytes to produce myelin, preve...

background: human umbilical cord blood (hucb) is an acceptable and readily accessible source of stem cells. there is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated hucb cells. the involvement of mirnas in several biological processes has been shown. the aim of this study was to ev...

objective: stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity.  the aim of  the present study was to examine in vitro and in vivo effects of  stevioside on rats  plasma levels of tumor necrosis factor- α (tnf-α),  interleukin-1β (il-1β), tnf-α and il-1β release from lipopolysaccharide(lps)-stimulated rat peripheral blood mononuclear cells (p...

introduction: in a prospective study, we aimed to assess the value of enhanced rdw to predict sepsis and evaluate factors affecting length of icu stay and in-hospital mortality among sepsis patients. material and method: after exclusion of 27 patients, we included 160 adult patients with suspicious sepsis admitted at university affiliated hospital with 33 icu-beds from 2010 to 2012. nighty pati...

background: in recent years we have successfully adopted an in vitro hepatogenic differentiation of mesenchymal stem cells (mscs). in this protocol the biologically active hepatocyte-like cells were differentiated from the stem cells isolated from either bone marrow or umbilical cord blood (ucb) samples. the aim of the present study was to compare the efficiency of the hepatogenic differentiati...

Leukemoid reaction like leukemia indicates noticeable increased count of WBCs (White Blood Cells) but the cause it is due to severe inflammation or infections in other body regions. In automatic diagnosis classifying and leukemoid reactions, ALL IDB2 (Acute Lymphoblastic Leukemia-Image Data Base) dataset has been used which comprises 110 training images blast cells healthy cells. This paper aim...

We numerically investigate margination of white blood cells and demonstrate the dependency on a number of conditions including hematocrit, the deformability of the cells and the Reynolds number. A detailed mesoscopic hydrodynamic Helfrich-type model is derived, validated and used for the simulations to provides a quantitative description of the margination of white blood cells. Previous simulat...

In recent years, dielectrophoresis based microfluidics systems have been used to manipulate colloids, inert particles, and biological microparticles, such as red blood cells, white blood cells, platelets, cancer cells, bacteria, yeast, micro‌organisms, proteins, DNA, etc. In the current study the governing electric potential equations have been solved in the presence of cell for the purpose of ...