We consider the problem of minimizing the number of wavelength interchangers in the design of wide-sense nonblocking crossconnects for wavelength division multiplexed (WDM) optical networks. The problem is modeled as a graph theoretic problem that we call dynamic edge coloring. In dynamic edge coloring the nodes of a graph are fixed but edges appear and disappear, and must be colored at the tim...

This paper presents the results of a crosstalk analysis of four optical wavelength division multiplexed (WDM) cross-connect (OXC) topologies. An optimal set of parameters is determined to reduce the total crosstalk. The scalability of the topologies is presented in terms of wavelengths and input fibers. The total crosstalk in function of the number of cascaded OXC’s is compared for the four top...

Polycomb group (PcG) proteins form essential epigenetic memory systems for controlling gene expression during development in plants and animals. However, the mechanism of plant PcG protein functions remains poorly understood. Here, we probed the composition and function of plant Polycomb repressive complex 2 (PRC2). This work established the fact that all known plant PRC2 complexes contain MSI1...

The Permanente Journal/ Summer 2004/ Volume 8 No. 3 Jimmy Hara, MD, FAAFP, long noted for his contributions on behalf of community health in the Los Angeles area, is taking a three-month sabbatical. While some take sabbaticals for rest and retreat, Dr Hara will be using his to increase linkages between community clinics and Kaiser Permanente (KP) Graduate Medical Education (GME) Residency Progr...

We previously reported a schizophrenia-associated polymorphic CT di-nucleotide repeat (DNR) at the 5'-untranslated repeat (UTR) of DPYSL2, which responds to mammalian target of Rapamycin (mTOR) signaling with allelic differences in reporter assays. Now using microarray analysis, we show that the DNR alleles interact differentially with specific proteins, including the mTOR-related protein HuD/E...

OBJECTIVE Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is largely a mystery. The peptide chemerin is a candidate for connecting fat deposits around the blood vessel (perivascular adipose tissue) to arterial contraction. We presently tested the hypothesis that chemerin is expressed in perivascular adipose tissue and is vasoactive, supporting the e...

As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator.

Companies like Equinix, CoreSite, and Telx manage and operate carrier-neutral colocation facilities (also called colos) where they provide, among other offerings, interconnection services. These facilities supply the infrastructure (e.g., rack space, cabling, power, and physical security) necessary for network operators to colocate their routers for easy interconnection. This work focuses on id...

The biological function and folding mechanisms of proteins are often guided by large-scale slow motions, which involve crossing high energy barriers. In a simulation trajectory, these fluctuations commonly identified using principal component analysis (PCA). Despite the popularity this method, complete its predictions based on physics protein motion has been so far limited. This study formally ...