W hear a lot these days about the concept of ‘‘evidence-based medicine.’’ Six years ago, one of our most illustrious and intelligent presidents also made it the subject of a presidential address. I will cover a little of the same ground, but bear withme andwewill sail into some different seas, as I will address the use of nonYevidence-basedmedicine in some aspects ofmodern medical care, rather ...

Two essential aspects of virtual screening are considered: experimental design and performance metrics. In the design of any retrospective virtual screen, choices have to be made as to the purpose of the exercise. Is the goal to compare methods? Is the interest in a particular type of target or all targets? Are we simulating a 'real-world' setting, or teasing out distinguishing features of a me...

This is an introduction to the panel “Workpractice Theory as Foundation for IS Research” on the ALOIS*2005 conference. It is also a position statement concerning workpractice theory. It describes the needs for a workpractice theory in information systems research. It describes briefly also the workpractice theory developed by Goldkuhl & Röstlinger. This is an example of a workpractice theory to...

Dicentric assay is the international gold standard for cytogenetic biodosimetry after radiation exposure, despite being very labour-intensive, time-consuming, and highly expertise-dependent. It involves the identification of centromeres and structure of solid-stained chromosomes and the enumeration of dicentric chromosomes in a large number of first-division metaphases of cultured T lymphocytes...

apical ballooning syndrome (abs) is a reversible cardiomyopathy with presentation mimicking an acute coronary syndrome. so in clinical practice, it is essential to consider it in the differential diagnosis of patients presenting with chest pain, especially in postmenopausal women. coronary angiography is usually indicated to achieve a proper diagnosis. typically, patients do not have significan...

T he paper by Bonow et al' in this issue of Circulation reports important empirical observations on measuring myocardial viability in humans with the potassium analogue thallium-201. After obtaining standard 20'1f exercise and redistribution images, a second dose of 201TI was injected and a third (reinjection) image was obtained beginning 10-15 minutes later. The reinjection images identified v...