background: the human leukocyte antigen-drb1 (hla-drb1) locus is one of the most polymorphic human loci and has a crucial role in the immune system. assessing the allelic frequencies of hla-drb1 locus would be a fundamental factor in defining the origin of populations, relationships with other populations, disease association studies and the constitution of unrelated bone marrow donor registrie...

potential relationships between amino acid motifs in the antigen binding groove of various alleles of the bovine major histocompatibility complex dr (bola-dr) molecule and peripheral blood mononuclear cell (pbmc) proliferation, in response to s. aureus and phytohemaglutinin, were investigated. the animals included in the study were approximately of the same age and comprised of pure holstein-fr...

Using SSR, a molecular marker, this study aimed to evaluate the genetic diversity and relationship among 55 herbaceous peony (Paeonia lactiflora Pall.) cultivars belonging Lactiflora, Hybrid Itoh Groups lay foundation for classification of cultivars, as well background analysis breeding new cultivars. Our results show that 86 alleles, 76 which were polymorphic, obtained by screening 13 pairs po...

Grain length is an important quantitative trait in rice (Oryza sativa L.) that influences both grain yield and exterior quality. Although many quantitative trait loci (QTLs) for grain length have been identified, it is still unclear how different alleles from different QTLs regulate grain length coordinately. To explore the mechanisms of QTL combination in the determination of grain length, fiv...

53 persons suspected to alpha1-antitrypsin deficiency detection (aatd) were investigated for zz, mz, zs, ss, and ms alleles analysis by serum protein electrophoresis (spe), measurement of trypsin inhibiting capacity (tic), isoelectric focusing (ief), polymerase chain reaction (pcr), and ief/pcr-rflp techniques. the result clearly shows by using spe and tic techniques only 35.85 % and 50.08% of ...

Abstract Mucopolysaccharidoses are lysosomal storage diseases characterized by the excessive accumulation of glycosaminoglycan sulfate in organs and tissues. To determine population allelic frequency MPS complex variants a without clinical molecular diagnosis MPS. An observational descriptive study was carried out where presents IDUA, IDS, SGSH, NAGLU, HGSNAT, GNS, GALNS, GLB1, ARSB, GUSB, HYAL...

In this study, morphological characteristics as well as ten of Simple Sequence Repeat (SSRs) loci were used to analyze the genetic diversity and relationships among 12 natural populations of Persian walnut (Juglans regia L.) in northern and western regions of Iran. The results showed that there was a high level of genetic diversity among the walnuts, both in terms of their SSRs loci as well as ...

Targeted gene mutation in the mouse is a primary strategy to understand gene function and relation to phenotype. The Knockout Mouse Project (KOMP) had an initial goal to develop a public resource of mouse embryonic stem (ES) cell clones that carry null mutations in all genes. Indeed, many useful novel mouse models have been generated from publically accessible targeted mouse ES cell lines. Howe...

The C. elegans heterochronic genes program stage-specific temporal identities in multiple tissues during larval development. These genes include the first two miRNA-encoding genes discovered, lin-4 and let-7. We show that lin-58 alleles, identified as lin-4 suppressors, define another miRNA that controls developmental time. These alleles are unique in that they contain point mutations in a gene...