In Western countries, the mutation status of the BRCA1 and BRCA2 genes is commonly determined for genetic counseling among members of families with a history of breast or ovarian cancer, especially for women of the Ashkenazi Jewish ethnicity. Recent studies in the Cancer Genome Atlas project have demonstrated that BRCA2 mutation carriers are more responsive to platinum-based chemotherapy among ...

This thesis presents the first measurement of 6 hadronic event shapes in proton-proton collisions at a center-of-mass energy of √ s = 7 TeV using the ATLAS detector at the Large Hadron Collider. Results are presented at the particle-level, permitting comparisons to multiple Monte Carlo event generator tools. Numerous tools and techniques that enable detailed analysis of the hadronic final state...

Fiber tracking provides insights into the brain white matter network and has become more and more popular in diffusion MR imaging. Hardware or software phantom provides an essential platform to investigate, validate and compare various tractography algorithms towards a "gold standard". Software phantoms excel due to their flexibility in varying imaging parameters, such as tissue composition, SN...

Radiotherapy planning requires accurate delineations of the critical structures. To avoid manual contouring, atlas-based segmentation can be used to get automatic delineations. However, the results strongly depend on the chosen atlas, especially for the head and neck region where the anatomical variability is high. To address this problem, atlases adapted to the patient's anatomy may allow for ...

PURPOSE To determine the repeatability and validity of a pattern-matching method for the segmentation and measurement of hippocampi on magnetic resonance (MR) images. MATERIALS AND METHODS Comparable two-dimensional MR images obtained in 18 subjects (nine healthy control subjects [six men, three women; aged 24-54 years] and nine patients with schizophrenia [six men, three women; aged 22-61 ye...

In these proceedings, a description of the reconstruction and identification methods for tau leptons in ATLAS at the LHC is presented. Identifying tau leptons is essential in many analyses, be it for Standard Model (SM) and Higgs boson signatures or searches for physics beyond the SM. The decay of the tau particle with leptonic as well as hadronic decay modes and its short lifetime makes it esp...

This paper gives a thorough overview of the ATLAS TDAQ SysAdmin group activities which deals with administration of the TDAQ computing environment supporting Front End detector hardware, Data Flow, Event Filter and other subsystems of the ATLAS detector operating on the LHC accelerator at CERN. The current installation consists of approximately 1500 netbooted nodes managed by more than 60 dedic...

Atlas Simulation: A Numerical Scheme for Approximating Multiscale Diffusions Embedded in High Dimensions by Miles Crosskey Department of Mathematics Duke University Date: Approved: Mauro Maggioni, Supervisor

The development and identification of best methods in fetal brain MRI analysis is crucial as we expect an outburst of studies on groupwise and longitudinal analysis of early brain development in the upcoming years. To address this critical need, in this paper, we have developed a mathematical framework for the construction of an unbiased deformable spatiotemporal atlas of the fetal brain MRI an...

Multi-atlas based segmentation methods have recently attracted much attention in medical image segmentation. The multi-atlas based segmentation methods typically consist of three steps, including image registration, label propagation, and label fusion. Most of the recent studies devote to improving the label fusion step and adopt a typical image registration method for registering atlases to th...