BACKGROUND Abacavir and lamivudine are approved for once-daily use in HIV-infected adults. Limited pharmacokinetic (PK) data for abacavir and lamivudine in children are available. METHODS A crossover study to compare PK of once- versus twice-daily abacavir and lamivudine was conducted in virologically suppressed HIV-infected Thai children aged <18years, with bodyweight of at least 14 kg, HIV ...

The authors have examined the relation between the Quetelet body mass index (BMI) and 26-year risk of all-cause mortality in a population of 12,576 non-Hispanic while, Seventh-day Adventist women (ages 30-74 years) who never smoked. Mortality risk for each BMI quintile (I, < 21.3 kg/m2; II, 21.3-22.9 kg/m2; III, 23.0-24.8 kg/m2; IV, 24.9-27.4 kg/m2; and V, > 27.4 kg/m2) was determined from a pr...

The effect of recombinant hirudin and the dosage of heparin on acute platelet-thrombus deposition during carotid angioplasty in anesthetized pigs was prospectively assessed. Fifty-five animals (mean weight, 33.9 kg) were randomized to one of six heparin dosages: heparin boluses of 35, 50, 100, 150, 200, or 250 units/kg followed by a continuous infusion of 35, 50, 100, 150, 200, or 250 units/kg/...

Peripheral chemoreceptor activity was studied in nine healthy, unsedated neonates (with a mean (SD) postconceptional age of 39 (2) weeks and birth weight of 3000 (400) g) by measuring the inhibition of ventilation elicited by five breaths of 100% oxygen (Dejours technique). Changes in tidal volume, frequency, and minute ventilation were measured before and after administration of aminophylline ...

Systemic administration of L-arginine alters renal haemodynamics in humans. We examined whether L-arginine-induced vasodilation of the renal vasculature is related to an increased production and release of NO by comparing the effects of L- and D-arginine on renal endothelium-dependent vasodilation. In a double-blind randomized cross-over study including 20 young, healthy male white subjects (ag...

The commented judgement concerns an allegation of discrimination in the recruitment process for studies preparing to become a military doctor, when national authorities denied female-applicant right take medical school entrance exam on basis her height (she was 150 cm tall and weighed 44 kg). Ministry National Defence argued that law required all personnel be able perform any mission, this mean...

To achieve malarial elimination, we must employ interventions that reduce the exposure of human populations to infectious mosquitoes. To this end, numerous antimalarial drugs are under assessment in a variety of transmission-blocking assays which fail to measure the single crucial criteria of a successful intervention, namely impact on case incidence within a vertebrate population (reduction in...

Voice quality is one of the most important source characteristics of a speaker’s speech production process, and creakiness is one of the variations of voice quality. This paper describes the development of an algorithm to automatically detect irregular phonation, including creakiness and other variations, in continuous running speech. The algorithm is an extension of the Aperiodicity, Periodici...

A new object tracking mask-based novel-look-up-table (OTM-NLUT) method is proposed and implemented on graphics-processing-units (GPUs) for real-time generation of holographic videos of three-dimensional (3-D) scenes. Since the proposed method is designed to be matched with software and memory structures of the GPU, the number of compute-unified-device-architecture (CUDA) kernel function calls a...

High-quality, monodisperse PbS-Au(1), PbS-Au(4), and PbS-Au(n) nanostructures have been synthesized via a facile and convenient solution chemistry approach. HRTEM images of these nanostructures showed good selectivity of gold deposition on the semiconductor in several spatially correlated directions. The formation of these regular nanostructures can be explained by the difference in polarity of...