BACKGROUND Although tissue hemorrhages, with resulting blood clots, are associated with glucose sensor implantation, virtually nothing known is about the impact of red blood cells and red blood cell clots on sensor function in vitro or in vivo. In these studies, we tested the hypothesis that blood can directly interfere with glucose sensor function in vitro. METHODS To test this hypothesis, h...

Knee ligament injuries frequently happen when the joint transitions from non-weight bearing (NWB) to weight bearing (WB). To gain insight into the mechanism that produces these injuries, physically active females (N = 41) and males (N = 39) underwent measurement of coupled tibiofemoral joint displacements [anterior tibial translation (ATT) and varus-valgus and internal-external rotations] and n...

R.A. Fisher questioned the sampling-based approach to statistical inference on the grounds that it often cannot really answer the scientific question of interest. Fisher’s fiducial argument and the Dempster-Shafer (DS) theory are inferential methods that strive towards answering these situation-specific questions. For some important problems, such as testing of a sharp null hypothesis, these al...

Paracoccidioidomycosis (PCM) is a serious infectious disease that progresses toward death if untreated. Its confirmatory diagnosis is made by the detection of the fungus Paracoccidioides brasiliensis in a direct mycological examination or by histopathology. However, these techniques are of low sensitivity. Serological tests seem to be more promising. The objective of this study was to test West...

AIM To investigate the effect of activation of canonical Wnt signaling pathway on the proliferation and differentiation of hepatic oval cells in vitro. METHODS WB-F344 cells were treated with recombinant Wnt3a (20, 40, 80, 160, 200 ng/mL) in serum-free medium for 24 h. Cell proliferation was measured by Brdu incorporation analysis; untreated WB-F344 cells were taken as controls. After treatme...

The Dempster–Shafer (DS) theory is a powerful tool for probabilistic reasoning based on a formal calculus for combining evidence. DS theory has been widely used in computer science and engineering applications, but has yet to reach the statistical mainstream, perhaps because the DS belief functions do not satisfy long-run frequency properties. Recently, two of the authors proposed an extension ...

Background. The use of plasma frozen within 24 hrs is likely to increase. Whole blood (WB) and buffy coats (BCs) can be held for a few hrs or overnight before processing. Methods. Twenty-four bags of WB for plasma and 12 bags for platelet (PLT) concentrates were collected. The fresh frozen plasma (FFP) was prepared within 6 hrs. I-FP24 and II-FP24 samples were prepared either from leukodepleted...

Background T2* relaxometry offers a non-invasive method to accurately quantify myocardial iron levels, thus aiding the diagnosis and assessment of prognosis of patients. Two T2* sequences are used clinically: the single breathhold multi-echo gradient echo white blood (WB) and black blood (BB) techniques. At 1.5T, BB T2* has superior reproducibility and fewer artefacts than WB T2*. We compared B...

Whole-body bone scintigraphy (WB-BS) is used for detecting and monitoring metastatic spread of prostate cancer (PCa) to investigate pain episodes. To the impact a positive WB-BS on pain-relieving medicine prescription in PCa patients, single-center, retrospective cohort study with patients classified as metastases (BM) by was conducted. Demographic, clinical, ambulatory data were evaluated. Pai...

BACKGROUND Sarcopenic Obesity (SO) is characterized by low lean and high fat mass; i.e. from a functional aspect a disproportion between engine (muscle) and mass to be moved (fat). At present, most research focuses on the engine, but the close "cross talk" between age-associated adipose and skeletal muscle tissue inflammation calls for comprehensive interventions that affect both components ali...