Interstitium contains a matrix of fibrous molecules that creates considerable resistance to water and solutes in series with the microvessel wall. On the basis of our preliminary studies, by using laser-scanning confocal microscopy and a theoretical model for interstitial transport, we determined both microvessel solute permeability (P) and solute tissue diffusion coefficient (D) of alpha-lacta...

A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development of tissue engineered constructs. A nonlinear biphasic displacement-velocity-pressure description was combined with adjective and diffusive solute transport, uptake and biosynthesis. To illustrate the approach we focused on the synthesis an...

The movement of assimilates from the sieve element/companion cell complex to sites of utilization has been examined in an extensive array of sinks possessing diverse anatomies. This work has been reviewed with respect to the pathways taken, the conductances and driving forces for movement along the pathways, and interaction between the apoplast and symplast. Most investigations to date have bee...

Strongly sorbing chemicals (e.g., heavy metals, radionuclides, pharmaceuticals, and explosives) in porous media are associated predominantly with the solid phase, which is commonly assumed to be stationary. However, recent fieldand laboratory-scale observations have shown that in the presence of mobile colloidal particles (e.g., microbes, humic substances, clays, and metal oxides), colloids can...

The field of hydrogeology is primarily concerned with the flow of water below the ground surface and with transport, normally of solutes and heat, within that water. Many disciplines have contributed to this endeavor which requires skills from across the spectrum of science, engineering and beyond. The diffusion equation describes not only solute transport but also the flow of water, via Darcy’...

The field of hydrogeology is primarily concerned with the flow of water below the ground surface and with transport, normally of solutes and heat, within that water. Many disciplines have contributed to this endeavor which requires skills from across the spectrum of science, engineering and beyond. The diffusion equation describes not only solute transport but also the flow of water, via Darcy’...

Peritoneal solute transport increases with time on treatment in a proportion of peritoneal dialysis (PD) patients, contributing to ultrafiltration failure. Continuous exposure of the peritoneum to hypertonic glucose solutions results in morphologic damage that may have a causative role in changes in peritoneal function. The purpose of this analysis was to establish whether increased exposure to...

Collecting duct cells swell when exposed to arginine vasopressin (AVP) in the presence of a transepithelial osmolality gradient. We investigated the mechanisms of AVP-induced cell swelling in isolated, perfused rat inner medullary collecting ducts (IMCDs) using quantitative video microscopy and fluorescence-based measurements of transepithelial water transport. We tested the roles of transepith...

Introduction The development and application of ground-water models has been an important component of USGS hydrologic investigations since the early 1970s. During the past 35 years, the USGS has developed a wide range of computer models to simulate saturated and unsaturated subsurface flow, solute transport, and chemical reactions. The most widely used of these programs is the MODFLOW model, w...

Flessner, Michael F., Jaehwa Choi, Heather Vanpelt, Zhi He, Kimberly Credit, Jeffrey Henegar, and Michael Hughson. Correlating structure with solute and water transport in a chronic model of peritoneal inflammation. Am J Physiol Renal Physiol 290: F232–F240, 2006. First published August 23, 2005; doi:10.1152/ajprenal.00211.2005.—To study the process of chronic peritoneal inflammation from steri...