نتایج جستجو برای: wasting disease

تعداد نتایج: 1495470  

Journal: :Current Opinion in Clinical Nutrition & Metabolic Care 2017

Journal: :Hypertension 2011
A Michael Tabony Tadashi Yoshida Sarah Galvez Yusuke Higashi Sergiy Sukhanov Bysani Chandrasekar William E Mitch Patrice Delafontaine

Congestive heart failure and chronic kidney disease are characterized by chronically elevated angiotensin II (Ang II) and muscle wasting. Ang II causes skeletal muscle wasting by reducing appetite and by enhancing catabolism. The serine/threonine kinase AMP-activated protein kinase (AMPK) functions mainly as a sensor of cellular energy status. It is energy sparing and favors ATP generation. We ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003
Steven Grinspoon Kathleen Mulligan

Weight loss and muscle wasting remain significant clinical problems, even in the era of potent antiretroviral therapy. In patients infected with human immunodeficiency virus (HIV), wasting, particularly loss of metabolically active lean tissue, has been associated with increased mortality, accelerated disease progression, loss of muscle protein mass, and impairment of strength and functional st...

Journal: :The Journal of clinical investigation 2004
Adriano Aguzzi Mathias Heikenwalder Gino Miele

The term "prion" was introduced by Stanley Prusiner in 1982 to describe the atypical infectious agent that causes transmissible spongiform encephalopathies, a group of infectious neurodegenerative diseases that include scrapie in sheep, Creutzfeldt-Jakob disease in humans, chronic wasting disease in cervids, and bovine spongiform encephalopathy in cattle. Over the past twenty years, the word "p...

Journal: :Prion 2013
Justin W Fischer Gregory E Phillips Tracy A Nichols Kurt C Vercauteren

Mechanisms for the spread of transmissible spongiform encephalopathy diseases, including chronic wasting disease (CWD) in North American cervids, are incompletely understood, but primary routes include horizontal and environmental transmission. Birds have been identified as potential vectors for a number of diseases, where they ingest or are exposed to infected material and later shed the disea...

Journal: :The Journal of clinical investigation 2004
Achim Thomzig Walter Schulz-Schaeffer Christine Kratzel Jessica Mai Michael Beekes

Recently, pathological prion protein PrP(Sc), the putative key constituent of infectious agents causing transmissible spongiform encephalopathies (TSEs), was found in muscles of rodents experimentally infected with scrapie and in patients with Creutzfeldt-Jakob disease (CJD). For the assessment of risk scenarios originating from these findings (e.g., alimentary transmission of pathogens associa...

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