Familial adult-onset primary torsion dystonia is an autosomal dominant disorder with markedly reduced penetrance. Most adult-onset primary torsion dystonia patients are sporadic cases. Disordered sensory processing is found in adult-onset primary torsion dystonia patients; if also present in their unaffected relatives this abnormality may indicate non-manifesting gene carriage. Temporal discrim...

INTRODUCTION: Use-dependent cortical plasticity has been the subject of some previous studies [1], [2]. However, there is not any study on the structural changes due to the academic occupation of mathematicians. Voxel Based Morphometry (VBM) permits us to make a voxel-based comparison of the local concentration of grey matter between two groups. In this study, we present a preliminary result of...

Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder characterized by uncontrollable urges to move the legs, causing chronic sleep disturbances. Brain iron deficiency has been considered as an important contributing factor to RLS [1-2]. In this study, we applied voxel-based relaxometry (VBR) for in vivo iron measurement and voxel-based morphometry (VBM) for morphological study ...

Posterior cortical atrophy (PCA) is characterized by basic visual and high order visual-spatial dysfunctions. In this study, we investigated long-distance deafferentation processes within the frontal-parietal-occipital network in ten PCA patients using a MRI-PET combined approach. Objective voxel-based [18F]FDG-PET imaging measured metabolic changes in single patients. Comprehensive investigati...

Objective: To investigate, and establish the neural correlates of, syntactic deficits in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)-ALS, as compared to primary non-fluent aphasia (PNFA) and controls. Method: Syntactic deficits were evaluated using a reduced version of the Test for Reception of Grammar (TROG) and voxel-based morphometry (VBM) analysis was conducted.

Participants: Sixty-six men, including 17 violent offenders with ASPD P, 27 violent offenders with ASPD−P, and 22 healthy nonoffenders participated in the study. Forensic clinicians assessed participants using the Structured Clinical Interview for DSM-IV and the Psychopathy Checklist–Revised. Main Outcome Measures: Gray matter volumes as assessed by structural magnetic resonance imaging and vol...

The parietal lobe is important for successful recognition memory, but its role is not yet fully understood. We investigated the parietal lobes' contribution to immediate paired-associate memory and delayed item-recognition memory separately for hits (targets) and correct rejections (distractors). We compared the behavioral performance of 56 patients with known parietal and medial temporal lobe ...

Chapter Two – A smaller amygdala is associated with anxiety in Parkinson's disease – a combined FreeSurfer-Voxel-based-morphometry study under review Two A smaller amygdala is associated with anxiety in Parkinson's disease – a combined FreeSurfer-Voxel-based-morphometry study Abstract Up to 50 percent of all Parkinson's disease (PD) patients develop symptoms of anxiety during the course of thei...

Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that running increases hippocampal volume by inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity by focalized irradiation is suffici...

The relationship between cortical grey matter density and media violence exposure in healthy male adolescents was investigated using voxel-based morphometry and the Childrens' Report of Exposure to Violence. Adolescents with more frequent exposure have lower left lateral orbitofrontal cortex density--a possible risk factor for altered socioemotional functioning.