Osmotic cell swelling activates Cl- channels to achieve anion efflux. In this study, we find that both the tyrosine kinase inhibitor herbimycin A and genetic knockout of p56lck, a src-like tyrosine kinase, block regulatory volume decrease (RVD) in a human T cell line. Activation of a swelling-activated chloride current (ICl-swell) by osmotic swelling in whole-cell patch-clamp experiments is blo...

Power quality issues have been a source of major concern in recent years due to extensive use of power electronic devices and non-linear loads in electrical power system. In power systems the common disturbances are voltage sags and swells, usually associated with power system faults. Therefore the effective detection of voltage sags and swells event is an important issue for both voltage sag a...

[1] The anomaly of radar sea spikes, defined here as the non-Bragg scattering events with backscattering cross-section of horizontal polarization exceeding that of the vertical polarization, has been associated with steep wave features possibly going through wavebreaking process, with or without whitecap manifestation. This property is exploited for using a dual polarized radar as a remote sens...

In this study, the authors hypothesized that in acute ischemic strokes, more permeable intracranial arterial thrombi (as opposed to less permeable thrombi) could be associated with better clinical outcomes and improved response to intra-arterial therapy. The authors examined the attenuation increase on computed tomographic angiography (CTA) and void fraction, using combination of noncontrast co...

The removal of potentially harmful radioactive waste from the anthroposphere will require disposal in geological repositories, designs which often favour inclusion a clay backfill or engineered barrier around waste. Bentonite is proposed as this and understanding its long-term performance behaviour vital establishing safety case for usage. There are many different compositions bentonite that ex...

In this study, the authors hypothesized that in acute ischemic strokes, more permeable intracranial arterial thrombi (as opposed to less permeable thrombi) could be associated with better clinical outcomes and improved response to intra-arterial therapy. The authors examined the attenuation increase on computed tomographic angiography (CTA) and void fraction, using combination of noncontrast co...

The effects of tight junction structure on water and solute fluxes across proximal tubular epithelium were examined with fiber-matrix equations previously derived by Curry and Michel (1980. Microvascular Research. 20:96-99). Using plausible estimates of tight junction fiber length and width the model predicts solute (Ps) and water permeability (Lp) coefficients that agree with the measured valu...

INTRODUCTION C-peptide measurement in blood or 24-h urine samples provides useful information regarding endogenous insulin secretion, but problems related to the rapid degradation of C-peptide in blood and difficulty of 24-h urine collection have limited widespread routine clinical use of this test. We assessed the feasibility of measuring urinary C-peptide (UCP) with correction for creatinine ...