The xanthan/chondroitin sulfate (X/CS) hydrogels, obtained by a crosslinking technique, were evaluated in vitro and in vivo as matrices for theophylline release. The influence of pH of simulated physiological media on the X/CS swelling behaviour at 37 ̊C was investigated. The hydrogels theophylline loading degree was evaluated by near infrared chemical imaging (NIR-CI) technique and confirmed al...

PURPOSE Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. METHODS A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 5...

It is not clear whether the muscle wasting commonly observed in hyperthyroidism is due to alteration in the rate of protein synthesis or degradation. The effect of experimental hyperthyroidism on skeletal-muscle proteolysis in the rat was studied by measuring alanine and tyrosine release from isolated skeletal muscles in vitro and 3-methyl-histidine excretion in vivo. Alanine release from the i...

Uniform drug delivery techniques are challenging to develop for the inner ear due complexity of cochlear anatomy. A promising solution is use biodegradable polymers because continuous release therapeutics without introducing toxic compounds desirable. Using a microneedle approach lends polymeric capability be placed inside scala tympani, releasing drugs overtime. Poly(lactic-co-glycolic acid) (...

Cell-Free Therapies hBMMSC-apoVs can promote mesenchymal stem cell (MSC) osteogenesis and inhibit osteoclast formation in vitro vivo. The mechanisms include the release of miR1324, which inhibits expression target gene SNX14, thereby activating SMAD1/5 pathway cells. In article number 2205813, Xiao Zhang, Yunsong Liu, co-workers suggest a therapeutic strategy for treatment bone loss, including ...

Veterinary vaccines in North America are regulated to assure that they are safe, pure, potent and effective. the veterinary biologics industry conducts a number of in vivo and in vitro assays as part of the vaccine development and manufacturing process to assure that vaccines conform to these requirements. the batch or serial release safety test is one such assay. the serial release safety test...