Certain epidemiological and experimental studies suggest that n-3 fatty acids and folate can reduce blood pressure (BP). We investigated the effect of a daily supplementation with dietary doses of B-vitamins or n-3 fatty acids for 5 years on BP in patients with a history of CVD who participated in the Supplémentation en Folates et Omega-3 trial. The patients (n 2501; 1987 men and 514 women) wer...

There is some evidence showing an inverse correlation between dietary sources including natural antioxidant vitamins and the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the effect of dietary antioxidants on oxidative stress in CVD patients. This study was carried out on 31 CVD patients and 63 healthy individuals. Nutritional status and dietary antioxidant vitamin...

Peripheral parenteral nutrition (PPN) solutions contain amino acids, glucose, and electrolytes, with or without some water soluble vitamins. Peripheral venous catheters are one of the causes of catheter related blood stream infection (CRBSI), which requires infection control. In Japan, PPN solutions have rarely been prepared under aseptic conditions. However, in recent years, the necessity of a...

The prevalence of asthma and other atopic disorders continues to increase worldwide. Examination of the epidemiologic patterns has revealed that this rise has occurred primarily in western, industrialised countries and countries transitioning to this lifestyle. While many changes have occurred in human populations over the years, it has been hypothesised that some of the relevant changes that h...

BACKGROUND The role of vitamins in the combat of disease is usually conceptualized as acting by modulating the immune response of an infected, eukaryotic host. We hypothesized that some vitamins may directly influence the growth of prokaryotes, particularly mycobacteria. METHODS The effect of four fat-soluble vitamins was studied in radiometric Bactec® culture. The vitamins were A (including ...

CONTEXT Vitamins B1 (thiamine), B3 (niacin), B6 (pyridoxine), and C (ascorbic acid) are vital for energy, carbohydrate, lipid, and amino acid metabolism and in the regulation of the cellular redox state. Some studies have associated low levels of water-soluble vitamins with metabolic syndrome and its various components. AIMS This study aims to determine the plasma concentrations of vitamins B...

OBJECTIVE To assess the antimutagenicity of antioxidant vitamins (vitamins A, C, and E) as expressed by their efficacy to lower aflatoxin-induced mutations. METHODS The Muller-5 method for mutation detection was used to assay the frequency of X-chromosome linked recessive lethal mutations (XRLMs) in Drosophila. Larvae were exposed to dietary concentration of aflatoxins and/or the human therap...

We have developed a new method to directly measure the concentration of the particulate and dissolved pools of B-vitamins in seawater. B-vitamins are coenzymes required for life, yet many organisms cannot synthesize these compounds de novo and must scavenge them from the environment. It has been shown that B-vitamins can control the marine microbial community’s structure and activity; however, ...

Vitamins are essential for improving and maintaining human health, and the main source of vitamins is the diet. Measurement of the quantities of water-soluble vitamins in common food materials is important to understand the impact of vitamin intake on human health, and also to provide necessary information for regulators to determine adequate intakes. Liquid chromatography (LC) and mass spectro...

OBJECTIVE To summarize results of clinical trials investigating the role of homocysteine (tHcy) as a risk factor for coronary artery disease (CAD) and the role of vitamin therapy (folic acid and vitamins B6 and B12) in primary and secondary prevention of CAD. QUALITY OF EVIDENCE MEDLINE was searched from January 1976 to January 1999 to locate cross-sectional, retrospective and prospective coh...