INTRODUCTION Nasal provocation testing involves an allergen-specific local reaction of the nasal mucosa to the administered allergen. AIM To determine the most objective nasal occlusion assessment technique that could be used in nasal provocation testing. MATERIAL AND METHODS A total of 60 subjects, including 30 patients diagnosed with allergy to common environmental allergens and 30 health...

We measured the microvascular response to histamine in guinea pig skin. Histamine (40 mg ml(-1)) was given either as a skin prick test or applied topically onto a skin window. The skin window was prepared by applying suction and gentle warming to the skin so that a blister was formed, and by removing the top of the blister. The microvascular response was measured as the accumulation of radiolab...

We investigated ventilation inhomogeneity during provocation with inhaled histamine in 20 asymptomatic nonsmoking subjects. We used N2 multiple-breath washout (MBW) to derive parameters Scond and Sacin as a measurement of ventilation inhomogeneity in conductive and acinar zones of the lungs, respectively. A 20% decrease of forced expiratory volume in 1 s (FEV1) was used to distinguish responder...

Sir, Urticaria is an immunologically mediated hypersensitivity reaction developing in both sexes. Although it may occur at any age, young females are more frequently affected [1]. Acute urticaria, shorter than six weeks, generally self-limited. In contrast, a patient with urticaria lasting weeks classified as having chronic urticaria. Patients be into either inducible or spontaneous (CSU). true...

Almost two-thirds of patients who visit a doctor for a reaction that is diagnosed as a ‘drug allergy’ (DA) are not allergic. This false claims of drug allergy leads to unnecessary avoidance of fi rst choice drugs, exposes the patient to less effective and potentially more toxic drugs, increases healthcare costs, and contributes to the development of antibiotic resistance. Therefore, a drug alle...

In panic disorder (PD) and agoraphobia with panic attacks, periodic panic attacks occur, characterized by the sudden onset of such physical symptoms as paresthesia, dizziness, palpitations, etc and are accompanied by a sensation of extreme fear (1). Panic attacks may be provoked by using some probes. Procedures that provoke symptoms of a specific illness have obvious value as tools for the stud...

BACKGROUND Children with congenital malformations, mental retardation, and complex early medical history frequently have feeding problems. Although tube feeding is effective in providing the necessary energy and nutrients, it decreases the child's motivation to eat and may lead to oral aversion. In this study, we sought to confirm our previous results, showing that a multidisciplinary clinical ...

BACKGROUND prolonged head-up tilt testing and sublingual nitrate provocation are increasingly used in the diagnosis of neurocardiogenic syncope. However there are few data regarding the results of these tests in asymptomatic older subjects. OBJECTIVE to assess the responses to the prolonged head-up tilt test followed by sublingual glyceryl trinitrate provocation in asymptomatic subjects over ...

Abstract Provocation by witchcraft, a defence to homicidal act supposedly perpetrated under the influence of belief in witchcraft and juju, has become plea frequently invoked witch-killers many African countries, particularly those formerly colonized Britain. Over last century, courts Anglophone Africa have repeatedly been invited address question as whether juju avails an accused person grave ...