The “state-of-art” treatment approach for patients with metastatic urothelial cancer (eg, bladder or other tumors of urinary tract) is platinum-containing chemotherapy, however, despite the high immediate efficacy therapy (up to 70% objective response rate), long-term results remain unsatisfactory, median progression-free and overall survival usually do not exceed 6 12 months respectively, visc...

Introduction: Von Hippel-Lindau disease (VHL) is autosomal dominant tumor syndrome that debuts mostly in young adults , patients with this are linked to the triggering of various types benign and malignant neoplasms multiple locations, systems organs, particular affecting more nervous system other internal organs. Approximately shows an incidence rate 1 36,000 live births a penetrance greater t...

Circulating tumor cells (CTCs) and circulating cancer-associated fibroblasts (cCAFs) have been individually considered strong indicators of cancer progression. However, technical limitations prevented their simultaneous analysis in the context CTC phenotypes different from epithelial. This study aimed to analyze CTCs cCAFs simultaneously peripheral blood 210 breast patients using DAPI/pan-kerat...

toxicity and drug resistance against pentavalent antimonials, medications of choice in treatment of leishmaniasis for more than 5 decades, have become important subjects globally. this study was a randomized, open labeled trial that was designed to determine efficacy and safety of imod as a novel herbal immunomodulator drug for treatment of canine visceral leishmaniasis (cvl).twenty healthy mon...

background: leishmaniasis is a tropical disease that is endemic in some areas of iran, including east azerbaijan . ifn-γ is one of the cytokines that triggers cell-mediated immunity, thus initiating elimination of the infection. this case-control study was performed to investigate the association between the polymorphism of the ifn-γ gene at the +874a/t locus and visceral leishmaniasis (vl). me...

background: although many studies had been conducted on various aspects of canine visceral leishmaniasis (cvl) in domestic dogs in the endemic areas of iran, investigations on cvl in wild canines are rare. methods : this is a cross-sectional study was conducted from december 2012 to 2013 in northeast of iran where human vl is endemic. wild canines were trapped around the areas where human vl ca...

background: dogs have been previously reported to be reservoirs of leishmania infantum as the etiological agent of human visceral leishmaniasis in iran. we report a case of canine visceral leishmaniasis (vl) caused by l. tropica from the north- west of iran where human visceral leishmaniasis is endemic. methods: the canine vl was initially screened by dipstick rk39 and direct agglutination test...

malakoplakia is a rare disease with undefined etiology that has been almost exclusively reported in urology and pathology journals. we are presenting a case of colonic malakoplakia in an i8-year old young man who was referred to us with a four-year history of intermittent rectorrhagia. the pathological examination of the endoscopically resected specimen revealed pathognomonic features of malako...

to investigate the effects of the two-pore-domain potassium (k2p) channel task-3 in a syngeneic murine model for malignant glioma. malignant or high-grade glioma (who grade iii and iv) are the most common and most aggressive primary brain tumors in adults. despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. however, recent phase i and ii trials hav...

A continuous monitoring of the whole tumor burden of individuals in orthotopic tumor models is a desirable aim and requires non-invasive imaging methods. Here we investigated whether quantification of a xenograft tumor intrinsic fluorescence signal can be used to evaluate tumor growth and response to chemotherapy. Stably fluorescence protein (FP) expressing cell clones of colorectal carcinoma a...