نتایج جستجو برای: virulence gene

تعداد نتایج: 1171817  

Journal: :Pharma innovation 2023

Endotoxin lipopolysaccharide (LPS) is the most powerful and effective immunostimulant key virulence factor produced by Escherichia coli (E. coli) accountable for many of inflammatory changes observed during bovine mastitis. In this study, whole-transcriptomic gene in peripheral blood mononuclear cells (PBMCs) stimulated with LPS were compared to control group analyzed RNA sequencing. A total 35...

Journal: :Journal of clinical microbiology 2003
Sadjia Bekal Roland Brousseau Luke Masson Gabrielle Prefontaine John Fairbrother Josée Harel

One approach to the accurate determination of the pathogenic potential (pathotype) of isolated Escherichia coli strains would be through a complete assessment of each strain for the presence of all known E. coli virulence factors. To accomplish this, an E. coli virulence factor DNA microarray composed of 105 DNA PCR amplicons printed on glass slides and arranged in eight subarrays corresponding...

2017
Marie Anne Chattaway Michaela Day Julia Mtwale Emma White James Rogers Martin Day David Powell Marwa Ahmad Ross Harris Kaisar Ali Talukder John Wain Claire Jenkins Alejandro Cravioto

PURPOSE This study investigates the virulence and antimicrobial resistance in association with common clonal complexes (CCs) of enteroaggregative Escherichia coli (EAEC) isolated from Bangladesh. The aim was to determine whether specific CCs were more likely to be associated with putative virulence genes and/or antimicrobial resistance. METHODOLOGY The presence of 15 virulence genes (by PCR) ...

2011
Jun Zheng Brian Ho John J. Mekalanos

A type VI secretion system (T6SS) was recently shown to be required for full virulence of Vibrio cholerae O37 serogroup strain V52. In this study, we systematically mutagenized each individual gene in T6SS locus and characterized their functions based on expression and secretion of the hemolysin co-regulated protein (Hcp), virulence towards amoebae of Dictyostelium discoideum and killing of Esc...

Journal: :PLoS Pathogens 2007
James C Charity Michelle M Costante-Hamm Emmy L Balon Dana H Boyd Eric J Rubin Simon L Dove

The MglA protein is the only known regulator of virulence gene expression in Francisella tularensis, yet it is unclear how it functions. F. tularensis also contains an MglA-like protein called SspA. Here, we show that MglA and SspA cooperate with one another to control virulence gene expression in F. tularensis. Using a directed proteomic approach, we show that both MglA and SspA associate with...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Mauricio H Pontes Eun-Jin Lee Jeongjoon Choi Eduardo A Groisman

Cellulose is the most abundant organic polymer on Earth. In bacteria, cellulose confers protection against environmental insults and is a constituent of biofilms typically formed on abiotic surfaces. We report that, surprisingly, Salmonella enterica serovar Typhimurium makes cellulose when inside macrophages. We determine that preventing cellulose synthesis increases virulence, whereas stimulat...

Journal: :Molecular biotechnology 2012
Taghi Zahraei Salehi Alfreda Tonelli Alberto Mazza Hamid Staji Pietro Badagliacca Iradj Ashrafi Tamai Reza Jamshidi Josée Harel Rossella Lelli Luke Masson

From the Camelidae family members, several serotypes of Escherichia coli (E. coli) have recently been isolated from diarrhoeic and non-diarrhoeic faecal samples. To date Shiga toxin-producing E. coli (STEC) strains have never been typed in one-humped camel (Camelus dromedarius). In the present study, two E. coli O157:H7 strains isolated from sick dromedaries were investigated. Virulence gene pr...

2010
Alex T. Nielsen Nadia A. Dolganov Thomas Rasmussen Glen Otto Michael C. Miller Stephen A. Felt Stéphanie Torreilles Gary K. Schoolnik

A fundamental, but unanswered question in host-pathogen interactions is the timing, localization and population distribution of virulence gene expression during infection. Here, microarray and in situ single cell expression methods were used to study Vibrio cholerae growth and virulence gene expression during infection of the rabbit ligated ileal loop model of cholera. Genes encoding the toxin-...

Journal: :Ciencia Rural 2023

ABSTRACT: The aim of this study was to molecularly identify different species Aeromonas isolated from farmed tambaqui (Colossoma macropomum) North Brazil, and evaluate their pathogenic potential by the presence virulence genes. From extraction bacterial DNA, PCR (polymerase chain reaction) primers 16S rDNA, aerA (cytolytic enterotoxin), ast (cytotoxic enterotoxin) act were performed. Of 24 isol...

Journal: :The American naturalist 2002
Sylvain Gandon Minus van Baalen Vincent A A Jansen

We analyze the evolutionary consequences of host resistance (the ability to decrease the probability of being infected by parasites) for the evolution of parasite virulence (the deleterious effect of a parasite on its host). When only single infections occur, host resistance does not affect the evolution of parasite virulence. However, when superinfections occur, resistance tends to decrease th...

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